Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male subjects

doi:10.3748/wjg.v21.i43.12457

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Randomized Clinical Trial

World J Gastroenterol. Nov 21, 2015; 21(43): 12457-12467
Published online Nov 21, 2015. doi: 10.3748/wjg.v21.i43.12457

Table 3 Clinical parameters in sulforaphane and placebo group participants before and after trial, Median (interquartile range)

	SF group (n = 24)		Placebo group (n = 28)
	Before	After	Before	After
BMI, kg/m²	25.7 (24.2-27.6)	25.8 (24.2-27.3)	25.9 (24.6-26.8)	25.6 (24.5-26.8)^a
Waist Circumference, cm	86.5 (81.0-95.0)	88.8 (82.5-95.0)	92.3 (88.4-95.3)	91.4 (88.5-97.1)
AST, IU/L	37.5 (24.8-48.3)	37.5 (27.0-39.8)	30.0 (27.5-39.5)	26.0 (22.5-42.8)
ALT, IU/L	54.0 (34.5-79.0)	48.5 (33.0-65.3)^a	41.5 (34.0-64.3)	40.5 (27.0-60.5)
γ-GTP, IU/L	51.5 (40.8-91.3)	50.0 (37.8-85.3)^a	52.0 (39.5-127.5)	53.0 (37-99)
Alb, g/dL	4.6 (4.4-4.9)	4.5 (4.3-4.7)^a	4.6 (4.5-4.7)	4.6 (4.5-4.8)
TB, mg/dL	0.9 (0.6-1.1)	0.9 (0.7-1.2)	0.9 (0.6-1.1)	0.8 (0.7-1.0)
ALP, IU/L	210 (168-248)	182 (166-140)^a	230 (206-274)	231 (214-281)
ChE, IU/L	390 (359-436)	388 (358-421)^a	398 (369-458)	406 (370-424)
Ferritin, ng/mL	281 (131-381)	216 (136-365)	231 (162-322)	215 (168-321)
UA, mg/dL	6.1 (5.5-7.0)	6.0 (5.4-6.8)	6.4 (5.4-6.8)	6.1 (5.6-6.7)
TG, mg/dL	146 (118-193)	135 (95.5-208)	133 (99.3-166)	113 (83.0-160)
TC, mg/dL	201 (182-219)	194 (184-211)^a	196 (183-224)	207 (184-225)
HDL-C, mg/dL	50.0 (44.0-59.0)	48.5 (44.8-54.0)	47.5 (44.8-58.0)	49.5 (45.0-57.0)
LDL-C, mg/dL	123 (107-138)	123 (111-141)	125 (116-142)	137 (118-146)
HbA1c, %	5.7 (5.4-6.1)	5.7 (5.5-6.0)	5.8 (5.5-6.1)	5.8 (5.5-6.1)
FBS, mg/dL	105 (99.8-113)	106 (101-115)	105 (99-115)	106 (97.5-115)
hs-CRP, mg/dL	0.067 (0.036-0.13)	0.059 (0.031-0.13)	0.056 (0.037-0.14)	0.068 (0.028-0.15)
8-OHdG, ng/mg-CRE	6.8 (5.5-9.0)	5.5 (4.9-6.7)^a	6.6 (5.3-8.4)	6.1 (4.7-7.6)
Adiponectin, μg/mL	6.1 (4.8-7.4)	4.8 (4.1-7.7)^a	6.3 (4.6-9.5)	6.1 (4.6-7.9)^a
Leptin, ng/mL	5.9 (4.2-7.5)	5.8 (3.0-8.7)	7.3 (5.2-11.4)	6.6 (4.1-10.1)

^aP < 0.05 vs before. AST: Aspartate-aminotransferase; ALT: Alanine aminotransferase; γ-GTP: γ-glutamyl transpeptidase; Alb: Albumin; TB: Total bilirubin; ALP: Alkali phosphatase; ChE: Choline esterase; UA: Urinary acid; TG: Triglyceride; TC: Total cholesterol; HDL-C: High-density lipoprotein cholesterol; LDL-C: Low density lipoprotein cholesterol; HbA1c: Hemoglobin A1c; FBS: Fasting blood sugar; hs-CRP: High-sensitivity C-reactive protein; 8-OHdG: 8-hydroxydeoxyguanosine; CRE: Creatinine; SF: Sulforaphane.

Citation: Kikuchi M, Ushida Y, Shiozawa H, Umeda R, Tsuruya K, Aoki Y, Suganuma H, Nishizaki Y. Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male subjects. World J Gastroenterol 2015; 21(43): 12457-12467
URL: https://www.wjgnet.com/1007-9327/full/v21/i43/12457.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i43.12457