Genetic and epigenetic aspects of initiation and progression of hepatocellular carcinoma

Table 4 Dysregulated microRNAs in hepatocellular carcinoma

microRNA	Sample	n	Relevant clinical factors	Functional analyses	Interacting molecules	In vivo	Ref.
miR-9	Tissue	200	OS, vascular invasion, stage	-	-	-	122
miR-21	Tissue	109	RFS, cirrhosis, stage	Growth	AP-1	Yes	129
miR-106b	Tissue	104	OS, size, vascular invasion	-	-	-	125
miR-122, miR-29	Serum	20	Liver damage	-	-	-	127
miR-128-2	Tissue, serum	182	OS, liver damage	-	-	-	132
miR-130a	Tissue	102	OS, gender, HBsAg status, size, stage	-	-	-	124
miR-130b	Tissue	97	OS, RFS, HBsAg status, AFP, size, grade, stage	-	-	-	126
miR-138	Tissue	180	OS, stage, vascular invasion, stage	-	cyclin D3	-	130
miR-148a	Tissue	297	OS, size	Proliferation, migration, invasion	ACVR1, BMP, Wnt	Yes	131
miR-224	Tissue	130	OS, RFS, AFP, stage, grade	-	pAKT	-	128
miR-331-3p	Tissue	108	OS, RFS, size, number, vascular invasion	Proliferation, migration, metastasis	PHLPP, AKT, EMT	Yes	123

miR: MicroRNA; OS: Overall survival; RFS: Recurrence free survival; HBsAg: Hepatitis B surface antigen; AFP: Alpha-fetoprotein.