Prognostic roles of preoperative α-fetoprotein and des-γ-carboxy prothrombin in hepatocellular carcinoma patients

Table 2 Univariate and multivariate analyses of factors associated with tumor recurrence in patients with hepatitis B virus infection

Variables	Univariate analysis			Multivariate analysis
	HR	95%CI	P value	HR	95%CI	P value
Age	0.977	0.952-1.003	0.086
Sex, male	1.077	0.512-2.264	0.843
Preoperative laboratory values
Aspartate transaminase	1.008	1.003-1.013	0.0011	1.001	0.993-1.010	0.778
Alanine transaminase	0.999	0.989-1.009	0.811
Platelets	1.001	0.979-1.024	0.929
Serum ALB	0.648	0.367-1.142	0.134
PT	0.974	0.953-0.996	0.0211	0.976	0.946-1.007	0.124
Serum TBIL	2.305	1.346-3.947	0.0021	4.068	1.586-10.436	0.0041
ICGR15	1.033	1.008-1.059	0.0111	0.967	0.919-1.018	0.967
Tumor markers
HH group	3.235	1.673-6.257	< 0.0011	2.464	1.086-5.587	0.0311
HL group	2.042	1.164-3.583	0.0131	1.083	0.497-2.360	0.841
Intraoperative data
Blood loss	1.001	1.000-1.001	0.0021	1.000	1.000-1.001	0.416
Surgical duration	1.002	1.000-1.004	0.0031	1.000	0.997-1.003	0.868
Pathologic results
Tumor size	1.148	1.068-1.234	< 0.0011	1.182	1.059-1.318	0.0031
Multiple tumors	1.363	1.152-1.612	< 0.0011	1.336	0.955-1.869	0.091
Vascular invasion	2.088	1.261-3.458	0.0041	2.624	1.408-4.892	0.0021

¹Represents statistical significance. HH group: Alpha-fetoprotein values > 529.8 ng/mL and des-gamma-carboxy prothrombin values > 60 mAU/mL; HL group: Alpha-fetoprotein values > 529.8 ng/mL or des-gamma-carboxy prothrombin values > 60 mAU/mL. ALB: Albumin; PT: Prothrombin; TBIL: Total bilirubin; ICGR15: Indocyanine green retention rate at 15 min.