Modulation of hepatic steatosis by dietary fatty acids

Table 1 Use of dietary supplement in the prevention of hepatic steatosis

Oil source	Oil fatty acid composition (%)		Experimental design	Results	Ref.
Krill	C14:0 C16:0 C18:0 C18:1 C18:2 C18:3 C20:5 C22:5 C22:6	2.5 18.2 2.8 25.8 54.4 4.9 5.3 2.3 3.0	C57BL/6 mice fed for 8 wk with a high-fat diet containing 1.25%-5% krill oil	↓ Hepatomegaly ↓ Hepatic steatosis ↓De novo lipogenesis ↓ Blood glucose	Tandy et al[50]
			Wistar rats fed for 6 wk with a diet containing 2.5% krill oil	↓ Hepatic steatosis ↓De novo lipogenesis ↓ Haematic triglycerides ↓ Haematic cholesterol	Ferramosca et al[43]
			Sprague-Dawley rats fed for 12 wk with a high-fat diet containing 2.5% krill oil	↓ Hepatic steatosis ↓De novo lipogenesis ↑ Fatty acid oxidation ↓ Mitochondrial uncoupling ↓ Haematic glucose ↓ Haematic insulin ↓ Haematic triglycerides	Ferramosca et al[42]
Pine nut	C16:0 C18:0 C18:1 C18:2 C18:3 C18:3 (5,9,12)	8.0 2.2 23.2 51.1 2.1 8.8	Mice fed for 8 wk with a diet containing 7.5% pine nut oil	↓ Liver weight ↓ Hepatic steatosis ↓De novo lipogenesis ↓ Haematic triglycerides ↓ Haematic cholesterol	Ferramosca et al[40]