Published online Feb 21, 2014. doi: 10.3748/wjg.v20.i7.1746
Revised: October 13, 2013
Accepted: November 3, 2013
Published online: February 21, 2014
Core tip: Dietary fats may not only influence the pathogenesis of liver diseases, but may also prevent and/or reverse their expression. This manuscript reviews the molecular mechanisms responsible for the regulation of hepatic lipogenesis, through which some fatty acids may be beneficial or detrimental to non-alcoholic fatty liver disease (NAFLD). We believe that an understanding of the biochemical mechanisms underlying fat accumulation in the liver will lead to more targeted and effective therapeutics for hepatic steatosis. This is a particularly important topic because NAFLD is an increasingly prevalent disease which, to date, has no proven pharmacologic treatment to prevent or reverse its course.