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World J Gastroenterol. Feb 21, 2014; 20(7): 1746-1755
Published online Feb 21, 2014. doi: 10.3748/wjg.v20.i7.1746
Published online Feb 21, 2014. doi: 10.3748/wjg.v20.i7.1746
Modulation of hepatic steatosis by dietary fatty acids
Alessandra Ferramosca, Vincenzo Zara, Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Università del Salento, I-73100 Lecce, Italy
Author contributions: Ferramosca A designed the manuscript and wrote the paper; Zara V designed the manuscript, wrote the paper and made critical revisions.
Correspondence to: Vincenzo Zara, Professor, Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Università del Salento, Via Provinciale Lecce-Monteroni, I-73100 Lecce, Italy. vincenzo.zara@unisalento.it
Telephone: +39-832-298705 Fax: +39-832-298626
Received: September 13, 2013
Revised: October 13, 2013
Accepted: November 3, 2013
Published online: February 21, 2014
Revised: October 13, 2013
Accepted: November 3, 2013
Published online: February 21, 2014
Core Tip
Core tip: Dietary fats may not only influence the pathogenesis of liver diseases, but may also prevent and/or reverse their expression. This manuscript reviews the molecular mechanisms responsible for the regulation of hepatic lipogenesis, through which some fatty acids may be beneficial or detrimental to non-alcoholic fatty liver disease (NAFLD). We believe that an understanding of the biochemical mechanisms underlying fat accumulation in the liver will lead to more targeted and effective therapeutics for hepatic steatosis. This is a particularly important topic because NAFLD is an increasingly prevalent disease which, to date, has no proven pharmacologic treatment to prevent or reverse its course.