Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Dec 28, 2014; 20(48): 18177-18188
Published online Dec 28, 2014. doi: 10.3748/wjg.v20.i48.18177
Figure 1
Figure 1 Interleukin-22 signaling pathway. IL-22 binds to a heterodimeric receptor composed of IL-10R2 and IL-22R1, activating JAK1 and TYK2, which self-phosphorylate, resulting in binding and phosphorylation of STAT3. Then, STAT3 translocates to the nucleus and induces target genes. IL: Interleukin; JAK: Janus kinase; TYK: Tyrosine protein kinase; STAT: Signal transducer and activator of transcription.