Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Nov 21, 2014; 20(43): 16184-16190
Published online Nov 21, 2014. doi: 10.3748/wjg.v20.i43.16184
Figure 2
Figure 2 Summary of the bio-chemical and clinical evidence of our proposed hypothesis. Ribavirin leads to passive hemolysis to release heme which activates HMOX1 in the liver and produces a synergistic effect with IFN on cHCV infection. HMOX1: Heme Oxygenase - 1; IFN: Interferon.