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©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Aug 21, 2014; 20(31): 10778-10789
Published online Aug 21, 2014. doi: 10.3748/wjg.v20.i31.10778
Published online Aug 21, 2014. doi: 10.3748/wjg.v20.i31.10778
Settings of hereditary PC | RR of PC (-fold) | Cumulative lifetime risk by age 70 (%) | Genes identified |
FPC syndrome | PALLD, CDKN2A, BRCA2, PALB2, ATM,….? | ||
FDR with PC | 2-3 | 2 | |
FDRs with PC | 6 | 8-12 | |
or more FDRs with PC | 14-32 | 40 | |
Hereditary cancer syndromes | |||
PJS | 132 | 36 | STK11/LKB1 |
MPCS/FAMMM | 13-47 | 17 | CDKN2A |
HBOC | 3.5-10 | 3-8 | BRCA1, BRCA2 |
LS | 8.6 | < 5 | MLH1, MSH2, MSH6 |
FAP | 2-3 | < 5 | APC |
Syndromes of chronic inflammation | |||
HP | 50-80 | 40 | PRSS1, SPINK1 |
CF | 5 | < 5 | CFTR |
- Citation: Ghiorzo P. Genetic predisposition to pancreatic cancer. World J Gastroenterol 2014; 20(31): 10778-10789
- URL: https://www.wjgnet.com/1007-9327/full/v20/i31/10778.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i31.10778