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Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Aug 21, 2014; 20(31): 10778-10789
Published online Aug 21, 2014. doi: 10.3748/wjg.v20.i31.10778
Table 1 Syndromes and genes associated with hereditary predisposition to pancreatic adenocarcinoma, relative and lifetime risk
Settings of hereditary PCRR of PC (-fold)Cumulative lifetime risk by age 70 (%)Genes identified
FPC syndromePALLD, CDKN2A, BRCA2, PALB2, ATM,….?
FDR with PC2-32
FDRs with PC68-12
or more FDRs with PC14-3240
Hereditary cancer syndromes
HBOC3.5-103-8BRCA1, BRCA2
LS8.6< 5MLH1, MSH2, MSH6
FAP2-3< 5APC
Syndromes of chronic inflammation
HP50-8040PRSS1, SPINK1