Topic Highlight
Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Aug 7, 2014; 20(29): 9872-9881
Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.9872
Figure 1
Figure 1 Molecular pathogenesis of sporadic colon cancer and colon cancer associated with inflammatory bowel disease. Many of the genetic alterations associated with development of sporadic colon cancer also play a role in colitis associated colon cancer. However, the frequency and sequence of these events differ between the cancers. Modified from Ref [21]. APC: Adenomatous polyposis coli; MSI: Microsatellite instability; KAS: Kirsten Rat Sarcoma Viral Oncogene Homolog; COX-2: Cyclooxygenase-2; DCC: Deleted in colorectal carcinoma; DPC4: Deleted in pancreatic carcinoma 4; CIN: Chromosomal instability.