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Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Jul 14, 2014; 20(26): 8377-8392
Published online Jul 14, 2014. doi: 10.3748/wjg.v20.i26.8377
Table 2 Current data on non-pharmacological treatments of non-alcoholic fatty liver disease
Ref.Sample sizeType 2 diabetesType of interventionStudy design/durationLiver enzymesImagingHistology
Kistler et al[111]813 adults25%Inactive or moderate or vigorous exerciseRetrospective analysis of biopsy-proven NAFLDVigorous recommendations was associated with ↓ GGT levels compared with being inactiveVigorous exercise was associated with a ↓ adjusted odds of NASH
Hallsworth et al[112]19 adultsResistance exerciseRandomly assigned to either exercise or standard care. 8 wkNo significant changes in ALT levelsResistance exercise: 13% relative ↓ in liver lipid by 1H-MRS
Bacchi et al[113]31 adults100%Aerobic (AER) or resistance (RES) trainingRandomized controlled study. 4 moHepatic fat content was ↓ in both by in-opposed-phase MR imaging
Mathurin et al[114]381 adults25%Bariatric surgeryProspective study. Follow-up of 5 yrSignificant ↓ in ALT and GGT levels 1 and 5 yr after bariatric surgerySignificant ↓ in NASH
Fibrosis ↑, 96% with F1
Mummadi et al[115]766 paired liver biopsiesBariatric surgerySystematic review and meta-analysis (15 studies)↓ or resolution 81.3% in NASH and 65.5% in fibrosis