miR-132 inhibits colorectal cancer invasion and metastasis via directly targeting ZEB2

Figure 4 miR-132 regulates epithelial-mesenchymal transition in colorectal cancer cells. A: Ectopic expression of miR-132 leads to a cobblestone-shaped epithelial-like form in LoVo cells; B: Knockdown of miR-132 leads to spindle-shaped mesenchymal characteristics in HCT116 cells; C, D: Overexpression of miR-132 increased the protein levels of epithelial markers (E-cadherin and α-catenin) but decreased the expression of mesenchymal markers (vimentin and fibronectin) in LoVo cells, whereas knockdown of miR-132 resulted in decreased levels of epithelial markers (E-cadherin and α-catenin) and increased levels of mesenchymal markers (vimentin and fibronectin) in HCT116 cells.