Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. May 28, 2014; 20(20): 6336-6344
Published online May 28, 2014. doi: 10.3748/wjg.v20.i20.6336
Table 1 Basic characteristics of the studies in the meta-analysis
Ref.YearSample sizen(M/F)Mean age (yr)TreatmentTumor vascular invasion (yes/no)Tumor stage (I-II/III-IV)Tumor differentiation (well/moderate-to-poor)Study quality (points)GPC3 detection methodSurvival analysisHazard ratioCounting method in immunohistochemistryCut-off level of “high” GPC3Number of patients with “high” GPC3 (n)
Shirakawa et al[27]2009107 (85/22)NRS47/60NR12/957/9IHCOSReported in textPercentage of positive cells> 10%87
Yorita et al[29]2010194 (142/52)NRS108/8682/11256/1387/9IHCOS/DFSReported in textPositive area score + Sp-Cm≥ 2-point score96
Ning et al[26]201261 (55/6)48SNR45/16NR6/9IHCOSReported in textPositive area score × staining intensity score> ‘‘+” (2-point score)32
Yu et al[30]2012100 (90/10)51S23/77NRNR6/9IHCDFSReported in textNRNRNR
Wang et al[28]201231 (29/2)49LT16/1512/196/256/9IHCDFSEstimatedPercentage of positive cells> 10%21