Editorial Open Access
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World J Gastroenterol. Jun 28, 2013; 19(24): 3713-3722
Published online Jun 28, 2013. doi: 10.3748/wjg.v19.i24.3713
Green tea and the risk of gastric cancer: Epidemiological evidence
I-Chun Hou, Saral Amarnani, Mok T Chong, Anupam Bishayee
I-Chun Hou, Saral Amarnani, Department of Clinical Research, American University of Health Sciences, Signal Hill, CA 90755, United States
Mok T Chong, Department of Pharmacy Practice, School of Pharmacy, American University of Health Sciences, Signal Hill, CA 90755, United States
Anupam Bishayee, Department of Pharmaceutical Sciences, School of Pharmacy, American University of Health Sciences, Signal Hill, CA 90755, United States
Author contributions: Hou IC performed literature search and collection as well as drafted the manuscript; Bishayee A performed additional bibliographic work as well as revised and edited the final manuscript; Amarnani S and Chong MT assisted Hou IC to write the first draft and reviewed the manuscript with constructive criticism.
Correspondence to: Anupam Bishayee, PhD, Department of Pharmaceutical Sciences, School of Pharmacy, American University of Health Sciences, 1600 East Hill Street, Signal Hill, CA 90755, United States. abishayee@auhs.edu
Telephone: +1-562-9882278 Fax: +1-562-9881791
Received: January 10, 2013
Revised: April 14, 2013
Accepted: May 9, 2013
Published online: June 28, 2013


Gastric cancer (GC) is one of the leading causes of cancer death in the world. Numerous efforts are being made to find chemoprotective agents able to reduce its risk. Amongst these, green tea has been reported to have a protective effect against stomach cancer. This article aims to critically evaluate all epidemiological studies reporting an association between green tea consumption and GC risk. MEDLINE, EBSCOHOST and Google Scholar were used to search for clinical trials of green tea and its correlation to stomach cancer. Studies include cohort and case-control studies. Outcome of interests are inverse association, no association, and positive association. Seventeen epidemiologic studies were reviewed. Eleven studies were conducted in Japan, five in China, and one with Japanese descendent in Hawaii. Ten case-control studies and seven cohort studies were included. The relative risks or odds ratio of GC for the highest level of green tea consumption was compared. Seven studies suggested no association, eight an inverse association, and one a positive association. One study had shown a significantly lowered GC risk when tea was served warm to cold. Another study also showed a significantly risk with lukewarm tea. All studies that analyzed men and women separately have suggested a reduced risk in women than in men, albeit no significant difference. This review demonstrates that there is insufficient information to support green tea consumption reduces the risk of GC. More studies on the subject matter are warranted.

Key Words: Gastric cancer, Green tea, Epidemiology, Case-control study, Cohort study

Core tip: Gastric cancer (GC) is one of the leading causes of cancer death in the world. Numerous efforts are being made to find chemoprotective agents able to reduce its risk. This review demonstrates that there is insufficient information to support green tea consumption reduces the risk of GC. More studies on the subject matter are warranted.


Gastric cancer (GC) is the fourth most common cancer and second leading cause of death from cancer throughout the world. A 2011 world analysis showed that 989600 new GC cases and 738000 deaths were estimated to have occurred in 2008[1]. The incidence of GC varies up to 10-fold across the world with the greatest percentage in China, followed by South Korea, South American countries and Japan[1]. These variations may be due to differences in environmental and lifestyle factors.

An excessive intake of protein, fat, salt or meat increases the risk of stomach cancer. Contrarily, dietary fiber, vegetables, fruit, and soy have been shown to play an important role in prevention of GC[2]. Tea, one of the most commonly consumed beverages in the world, has been reported in pre-clinical and epidemiological studies to provide protective effects against GC[3]. Green tea and its constituents have been shown to exhibit multiple health benefits[4-6]. Green tea and its bioactive constituents inhibit tumorigenesis in many animal models, including those for cancer of the skin, lung, oral cavity, esophagus, stomach, small intestine, colon, liver, pancreas, bladder, breast, and prostate[7-11].

Polyphenols, which include flavanols, flavandiols, flavonoids, and phenolic acids, constitute the most interesting group of green tea leaf components. Most green tea polyphenols (GTPs) are flavonoids. Flavonoids are phenol derivatives synthesized in substantial amounts (0.5%-1.5%) and variety (more than 4000 flavonoids identified), and widely distributed among plants[12]. The main flavonoids present in green tea are catechins. Catechins are colorless, astringent, water soluble compounds, and are readily oxidizable. Since green tea does not undergo fermentation, it contains greater amounts of various catechins than in black or oolong tea. Traces of catechins are also found in grapes, wine, and chocolate[13]. The four kinds of catechins found mainly in green tea include: (-)-epicatechin-3-gallate (ECG), (-)-epigallocatechin, (-)-epicatechin, and (-)-epigallocatechin-3-gallate (EGCG). Out of the above, EGCG accounts for more than 40% of the total catechin content. Figure 1 shows the chemical structure of the four major catechins present in green tea. EGCG is the most abundant polyphenol in green tea and has gained most attention as the active constituent responsible for the anticarcinogenic activity of this tea. One cup of brewed green tea (2.5 g of green tea leaves/200 mL of water) may contain 90 mg of EGCG[14]. In black tea, the catechins compounds such as theaflavins and thearubigins predominate. Black and green tea both contains similar amounts of flavonoids, however they differ in their chemical structure; green tea contains more catechins (simple flavonoids). Conversely, the oxidation undergone by black tea processing converts these simple flavonoids into theaflavins and thearubigins[12].

Figure 1
Figure 1 Structures of green tea catechins.

The first green tea clinical trial with cancer patients as a phase I study using green tea capsules was performed in 1997 and later published in 2001[15]. The purpose of this study was to determine the maximum-tolerated dose, toxicity, and pharmacology of oral green tea extract. A total of 49 cancer patients with solid tumors were studies. There were two treatment arms in this two years study: 0.05-5.05 g/m2 once daily dose and 1.0-2.2 g/m2 three-times-daily for 6 mo. The maximum tolerated dose was 4.2 g/m2 once daily or 1.0 g/m2 three times a day. This study recommended that 1.0 g/m2 for three times daily should be considered for future clinical trials and that doses studied can be taken safely for at least 6 mo[15]. Thereafter, several phase I studies on healthy volunteers have also been conducted to define the basic pharmacokinetic parameters and safety profile for oral consumption of various types of green tea preparations[16,17]. In 2003, a phase I study investigated polyphenon E™ (a defined, decaffeinated GTP mixture) in healthy individuals[18]. The study concluded that greater oral bioavailability of EGCG can be achieved by taking the polyphenon E™ capsules on an empty stomach after an overnight fast. Recent phase I studies have concluded that the consumption of green tea appears to be relatively safe (8-16 cups of green tea once a day or in divided doses twice a day for 4 wk)[3]. However, up to 2 g orally twice per day was observed to be well tolerated in patients with stage 0 to II chronic lymphocytic leukemia[19]. Bettuzzi et al[20] had reported that 600 mg of daily catechin extract had a statistically significant protective effect in patients with high-grade prostate intraepithelial neoplasia. EGCG delivered in the capsule form (200 mg/d for 12 wk) has also been reported to be effective in patients with human papilloma virus-infected cervical lesions[21].

Although many clinical trials have been conducted to explore the safety and efficacy of green tea extract in cancer patients, similar studies in GC patients have not yet been executed. Over the last three decades, a number of epidemiological studies were conducted to investigate the association between green tea consumption and stomach cancer risk in human subjects[22-27]. Nonetheless, the epidemiologic studies have not yielded clear conclusions concerning the protective effects of tea consumption against cancer formation in humans. The aim of this systematic and up-to-date review was to critically evaluate all epidemiological studies published so far to report an association between green tea consumption and GC risk.

Database and search strategy

Research articles presented in this review includes epidemiological studies of green tea consumption in relation to GC risks. Epidemiological studies were retrieved through three computerized literature search engines: PubMed (Medline), American University of Health Science’s literature database EBSCOHOST, and Google Scholar. All 5490 journals in PubMed and 32 publications in EBSCOHOST are utilized in the search. Only articles published between 1990 and 2012 were retrieved. The major descriptor key words used for the search were stomach cancer, GC, green tea, Camellia sinensis, EGCG, polyphenol, catechin and the minor descriptor key words used were tumor, cancer, lesion, polyp, adenocarcinoma. The identifiers used were risk, prevention, treatment, prolong disease. In addition, relevant publications retrieved from reference lists were manually searched to be included in this review. Abstracts were reviewed and studies retrieved in full.

Inclusion criteria

Only case-control studies, cohort studies, and prospective studies reporting association between green tea and stomach cancer risk were included. Articles specifying the number of GC cases and controls for case-control studies, odds ratio (OR) or relative risk (RR) and its corresponding 95%CI for highest versus non/lowest levels of tea intake are presented in this review.

Exclusion criteria

In vitro cell culture and animal studies were excluded. Papers that failed to report the number of individuals (cases and controls) involved in the study and the level of green tea consumption (amount or frequency of green tea consumed) were also excluded. Articles written in foreign languages, as well as abstracts, were excluded since the complete publications were not available for this review work.

Data extraction

All articles were read in full. From those studies finally selected, the following data were extracted: study design, study name (first author, publication year), region and study period (years), population size, green tea consumption level, OR or RR with 95%CI of the highest consumption level, and adjustments.


This review included a total of 17 epidemiological studies (10 case-control studies[28-37] and 7 cohort studies[38-44] published between 1988 and 2010. Figure 2 displays a flow diagram of the procedure used to identify the studies included in this review. There were 210 papers relevant to the words used for the search. Through the steps of title screening, 125 studies were excluded (16 duplicate articles, 31 articles not in English, and 78 were not epidemiologic studies). Abstracts from 85 articles were reviewed and an additional 67 studies were excluded (33 were not epidemiologic studies, 34 were not conducted in humans), resulting in 18 articles for full publication review. Of these, 7 were excluded (5 were not green tea, 2 did not report usable data). Of the remaining 11 articles, six articles were identified from the reference lists and are included in this review. As a result, 17 articles were found to meet the inclusion criteria described above.

Figure 2
Figure 2 Flow diagram of identification of relevant studies.

Eleven studies were conducted among the Japanese population in Japan[28-30,33,35,39-44], five studies were conducted among the Chinese population in China[31,32,34,36,37], and others were conducted among the Japanese-born population in Hawaii, United States[38]. All of the Chinese studies were case-control studies. RR, OR, 95%CI of the highest green tea consumption levels were included. Table 1 represents the main characteristics of the studies included in this review.

Table 1 Characteristics of epidemiological studies on green tea consumption and stomach cancer risk.
Ref.Region and observation periodStudy population1Green tea consumption levels2RR or OR (95%CI)3Direction of associationAdjustments
Case-control studies
Kono et al[28], 1988Kyushu, Japan, 1979-1982139 GC cases ≤ 4 cups/dHC: 0.5 (0.3-1.1)Inverse (significant) with high consumptionAge, gender, cigarette smoking, mandarin oranges and other fruits
2574 HC5-9 cups/dPC: 0.3 (0.1-0.7)
278 PC≥ 10 cups/d
Kato et al[29], 1990Aichi, Japan, 1985-1989427 GC cases1-4 cup/dMales: 1.01 (0.70-1.47)NoneAge, gender, residence (metropolitan area in Aichi prefecture, other areas of Aichi prefecture, and other prefectures)
3014 HC≥ 5 cups/dFemales: 0.81 (0.51-1.27)
Hoyoshima et al[30], 1992Saitama, Japan, 1984-1990294 GC cases ≤ 4 cups/dHC: 1.3 (0.8-2.1)Minimal to positiveAge, gender, residence, cigarette smoking
202 HC5-7 cups/dPC: 0.8 (0.5-1.3)
294 PC≥ 8 cups/d
Yu et al[31], 1995Shanghai, China, 1991-1993711 GC casesNon drinkersTemperature: 0.71 (0.54-0.93)Inverse (significant with warm/cold green tea)Age, education, birthplace, alcohol drinking, cigarette smoking, intake of fresh fruit, vegetables and preserved fruit
711 matched PCDrinkersBoiling hot: 1.18 (0.75-1.86)
Hot: 0.63 (0.46-0.87)
Warm/cold: 0.51 (0.29-0.91)
Ji et al[32], 1996Shanghai, China, 1988-19891124 GC casesNon drinkersMales: 0.76 (0.55-1.27)InverseAge, income, and education among women; further adjusted for smoking and alcohol drinking among men
1451 matched PCMales:Females: 0.81(0.46-1.43)
≤ 1200 g/yr
≤ 2000 g/yr
≤ 3000 g/yr
≤ 1200 g/yr
> 1200 g/yr
Inoue et al[33], 1998Nagoya, Japan, 1990-1995893 GC casesRarely0.69 (0.48-1.00)InverseAge, gender, year and season at first hospital visit, habitual smoking, habitual alcohol drinking, regular physical exercise, intake of coffee, black tea, fruit, rice and beef
21128 HC≥ 7 cups/ d
Setiawan et al[34], 2001Yangzhong, China, 1995133 GC casesNon drinkers0.39 (0.15-1.01)Inverse (significant)Age, gender, body mass index, cigarette smoking, alcohol drinking
433 PC1-21 cups/wk
> 21 cups/wk
Hoshiyama et al[35], 2004Japan, 1988-1990157 GC cases< 1 cup/d1.20 (0.6-2.5)NoneAge, gender, cigarette smoking, H. pylori infection, history of peptic ulcer, family history of stomach cancer, educational level, consumption of rice, miso soup, green-yellow vegetables, white vegetables, fruits, preference for salty foods
285 PC1-2 cups/d
3-4 cups/d
5-9 cups/d
≥ 10 cups/d
Mu et al[36], 2005Taixing, China, 2000206 GC casesNon-drinkers0.39 (0.17-0.91)InverseAge, gender, education, income, body mass index, cigarette smoking, alcohol drinking, very hot food eating habit, H. pylori infection, stomach disease, family history of stomach cancer
415 PC> 250 g/mo
Deandrea et al[37], 2010Harbin, China, 1987-1989266 GC casesNon-drinkersTemperature: 0.87 (0.60-1.25)Inverse (significant with lukewarm green tea)Age, gender, education level, cigarette smoking
533 HC< 750 g/ yrHot: 1.27 (0.85-1.90)
≥ 750 g/yrLukewarm: 0.19 (0.07-0.49)
Prospective cohort studies
Galanis et al[38], 1998Hawaii, Unites States, 1975-1994108 GC casesNon-drinkers1.5 (0.9-2.3)PositiveAge, gender, years of education and Japanese place of birth
11907 Japanese residents1 cup/dMales: 1. 6 (0.9-2.9)
> 2 cups/dFemales: 1.3 (0.6-2.6)
Nakachi et al[39], 2000Saitama, Japan488 GC cases ≤ 3 cups/d0.59 (0.35-0.98)InverseCigarette smoking, alcohol drinking, intake of green and yellow vegetables, intake of rice
8552 adults4-9 cups/dMales: 0.54 (0.22-1.34)
≥ 10 cups/dFemales: 0.57 (0.34-0.98)
Tsubono et al[40], 2001Miyagi, Japan, 1984-1992419 GC cases< 1 cups/d1.2 (0.9-1.6)NoneAge, gender, type of health insurance, history of peptic ulcer, cigarette smoking, alcohol consumption, consumption of rice, black tea, coffee, meat, green or yellow vegetables, pickled vegetables, other vegetables, fruits and bean-paste soup
26311 adults1-2 cups/dMales: 1.5 (1.0-2.1)
3-4 cups/dFemales: 0.8 (0.5-1.3)
≥ 5 cups/d
Nagano et al[41], 2001Hiroshima Nagasaki, Japan, 1979-1981901 GC cases0-1 cups/d0.95 (0.76-1.2)NoneAge, gender, city of residence, radiation exposure, cigarette smoking, alcohol drinking, body mass index, education level
37639 adults2-4 cups/d
≥ 5 cups/d
Hoshiyama et al[42], 2002Japan (nationwide), 1988-1997359 GC deaths< 1 cups/dMen: 1.0 (0.5-2.0)NoneAge, smoking, history of peptic ulcer, family history, consumption of rice, miso soup, green-yellow vegetables, fruits and preference for salty foods
72851 adults1-2 cups/dWomen: 0.7 (0.3-2.0)
3-4 cups/d
5-9 cups/d
≥ 10 cups/d
Fujino et al[43], 2002Japan (nationwide), 1988-1990379 GC deathsEverydayMales: 1.11 (0.75-1.63)NoneAge, gender, cigarette smoking, alcohol drinking, diet, sporting activities, medical history, education level
328030 adults ≤ 3 times/dFemales: 1.43 (0.78-2.62)
> 3 times/d
Sasazuki et al[44], 2004Japan (nationwide)892 GC cases< 1 cups/dMales: 0.97 (0.77-1.22)NoneAge, area, cigarette smoking, consumption of fruit, green-yellow vegetables, fish gut, miso soup, rice, black tea and coffee
Cohort I: 1990-200172943 adults1-2 cups/dFemales: 0.70 (0.47-1.05)
Cohort II: 1993-19993-4 cups/d
≥ 5 cups/d

Three hospital-based case control studies were carried out in Japan[29,33] and China[37]. In all investigations, all cases were confirmed histologically and controls were free of gastrointestinal diseases. Information on green tea consumption, as well as lifestyle habits and family history, was obtained through a self-administered questionnaire before the final diagnosis. Adjustments were made for age, gender, place of residence[29], age, gender, year and season at first hospital visit, smoking and alcohol drinking status, physical exercise, intake of coffee, black tea, fruit, rice and beef[33], or age, gender, education level, and smoking status[37]. The RRs or ORs were calculated using, as reference category, subjects who drank less than 1 cup/d, or non-drinking subjects[33,37]. Although Kato et al[29] did not find an association between green tea consumption and GC risk, Inoue et al[33] and Deandrea et al[37] showed that the frequent consumption of green tea (≥ 7 cups/d and ≥ 750 g/year, respectively) decreased the risk of GC. Furthermore, Deandrea et al[37] observed a significant decrease in GC risks amongst drinkers of green tea at lukewarm temperature.

Five population-based case control studies were conducted in Japan[35] and China[31,32,34,37]. Cancer cases were confirmed pathologically[34,37], histologically[31,32] or by other methods[35]. In some epidemiological studies, controls were randomly selected[32,34,36] and matched according to age and gender[31,32,35], or study area[35]. Information was either obtained through interview[31,32,34,37] or administration of questionnaires[35]. Adjustments were made for age, education, birthplace, alcohol and cigarette usage, fresh fruit, vegetable and preserved fruit intake[31]; age, income, education among women and further adjusted for smoking and alcohol drinking among men[32]; age, gender, body mass index, cigarette smoking, and alcohol drinking[34]; and age gender, education, income, body mass index, smoking and alcohol drinking, very hot food eating habit, Helicobacter pylori (H. pylori) infection, stomach disease, family history of GC[35]. The RRs or ORs were calculated using, as reference category, non-tea drinkers[31,32,34,36] or low consumption of green tea[35]. Four of these five studies reported an inverse association between green tea consumption and the risk of GC[31,32,34,36]. The investigation conducted in Japan did not report any association[35]. Yu et al[31] reported that drinking warm or cold tea was associated with significant decreased GC risk compared with non-drinkers. This coincides with the findings of Deandrea et al[37] that there is a significant inverse association with consuming lukewarm green tea and GC risk.

Two population-hospital-based case control studies were conducted in Japan[28,30]. In both studies, cases were histologically diagnosed and hospital controls were recruited. Information from cases and hospital controls, as well as population controls, on the frequency and amount of green tea consumption was obtained by interview. Interviews were performed by the public health nurses and hospital staff[28] or by the authors and colleagues[30]. In both studies, the interview on cases and hospital controls were conducted before diagnostic procedures. The results were adjusted for age, gender, smoking, intake of mandarin oranges and other fruits[28]; and age, gender, residence, and smoking status[30]. The RRs for both studies were compared intermediate and high consumption with low consumption of green tea. Kono et al[28] observed a significantly decreased GC risk with high consumption of green tea (10 or more cups/d) compared to both hospital and population controls. However, Hoshiyama et al[30] observed a minimal to positive association in hospital and population controls.

All of the seven cohort studies were carried out among the Japanese population[38-44]. However, one was conducted in Hawaii, United States[38]. Information on the frequency and amount of green tea consumed and on other lifestyle factors was obtained by a self-administered postal questionnaire. In two of the seven cohort studies, the validity of the food frequency questionnaire was evaluated[42,44], and in two of the seven cohort studies the questionnaire was checked by interviewers[40,41]. In the study by Galanis et al[38] of 11907 randomly selected Japanese residents of Hawaii, 108 participants developed GC (follow-up period of 14.8 years on average). The study by Nakachi et al[39] on 8552 residents in Saitama Prefecture, Japan found 488 deaths from GC (follow-up period of 11 years). In the study by Tsubono et al[40] on 26311 residents of the Miyagi Prefecture, 419 participants developed GC (follow-up period of 9 years). Nagano et al[41] examined 37639 atomic bomb survivors, and of those 901 participants developed GC (follow-up period of 15 years). In the study by Hoshiyama et al[42] on 72851 Japanese residents, 359 subjects died of GC (follow-up period of 7 years). In the study by Fujino et al[43] on 328030 Japanese residents, 345 subjects died of cancer (follow-up period of 7 years). Finally, in the study conducted by Sasazuki et al[44] of 72943 Japanese residents, 892 participants developed GC (follow-up period of (follow-up period of 10 years). In all cohorts studies, some adjustments were made: age[38-44], gender[38-41,44], years of education[38,41,43], cigarette smoking (for men only)[38-44], alcohol consumption (for men only)[39-41,43], place of birth[38], history of peptic ulcer[40,42], body mass index[41], coffee consumption and several other foodstuffs[39,40,42,43]. RRs of the highest green tea consumption levels were included instead for all consumption levels. In all studies, some adjustments were made: gender, age, years of education, cigarette smoking, alcohol consumption, place of birth, family history of GC, body mass index, coffee consumption and several other foodstuffs. The RRs were calculated using, as reference category, either non-drinkers[38] or the lowest level of green tea consumption[39-44]. In the first cohort study, Galanis et al[38] reported a non-significant increased risk of GC associated with green tea consumption. In contrast, Nakachi et al[39] reported a slight inverse association between green tea consumption and GC risks. The other five cohort studies found no association between green tea consumption and GC incidence[40-44].


Green tea contains polyphenols, powerful antioxidants that act as chemopreventive agents. EGCG is considered the major polyphenol that constitute to green tea’s preventive constitute. Significant amounts of in vitro studies with human cancer cells as well as in vivo studies with animal models and have investigated the mechanism of EGCG for its anticarcinogenic properties. EGCG blocks multistage carcinogenesis by modulating a wide spectrum of signal transduction pathways, including mitogen-activated protein kinases, Janus kinase-signal transducer and activator of transcription, phosphoinositide 3-kinase/protein kinase B, Notch, nuclear factor-κB and Wnt/β-catenin, involved in cell proliferation, transformation, apoptosis, inflammation, invasion and metastasis[45]. Accumulative studies show another green tea catechin ECG can also interfere with multiple cell signaling pathways and has multiple cellular targets which are likely to interact in concert to reduce the risk of cancer[46]. Several clinical studies with human subjects have also demonstrated that consumption of green tea as well as EGCG exert beneficial effects[45]. However, epidemiologic studies are somewhat limited with mixed results. Of the 17 epidemiological studies investigated in this review, eight have no association[29,30,35,40-44], eight have inverse association[28,31-34,36,37,39], and one has positive association[38]. Table 2 provides a summary of findings. A trend observed is that decreased risk was associated with an increased green tea consumption level. The studies conducted in China showed a stronger reduction in GC among green tea drinkers than those conducted in Japan. A few authors have argued that the relative lack of subjects in Japan who do not drink green tea may have resulted in an insufficient number of non-drinkers, and this might be an explanation for the weaker association among Japanese studies[36,41,47]. In terms of study design, prospective/cohort studies are considered to be more reliable than case-controlled studies because of the large population size. However, the value of a study depends not only on the type of design, but also on the overall quality. This review identified seven cohort studies which examined the association between cancer risk and green tea consumption. Of these, the smallest study observed an inverse association[39], whereas the five largest studies observed no association[40-44]. One study found a non-significant positive association[38].

Table 2 Summary of findings: Number of epidemiological studies with its reported direction of association between green tea consumption and gastric cancer risk.
Study designDirection of association
Case-control studies73010
Cohort studies1517

A negative association is stronger in case-control studies than in cohort studies. Seven of the ten case-control studies have suggested an association of green tea consumption and reduced GC risk[28,31-34,36,37], whereas only one of the seven cohort studies showed a reduced GC risk[39]. These discrepancies may be partly associated with the limitations of case-control design: recall, information, selection, and confounding biases. Cancer patients may recall their dietary habits differently from healthy controls, and healthy controls are rarely representative of the population as a whole and tend to report a healthy dietary habit[36]. In retrospective studies like case control studies, the decreased consumption of green tea after abdominal symptoms due to GC may have biased the patient’s recall of past consumption, resulting in underestimating the patient’s true intake on green tea. Moreover, present dietary habits might influence the accuracy of recalling past dietary habits. In case-control studies, there may be a problem with the reliability of information, because information that exposes the past history is collected after cancer is diagnosed. In all studies included in this review, selection and confounding bias was minimized (i.e., cases and controls were drawn from the same population; adjustment for certain factors). However, in hospital-based case control studies, the controls were not free of diseases. Furthermore, self-selection bias could not be excluded because information was obtained by questionnaire survey. Only one cohort study (reporting no association between green tea consumption and GC risk) showed limitations due to selection bias[30].

The non-significant findings regarding the effects of green tea consumption on GC risk in this review contradicts the results of previous experimental studies on this topic using in vivo animal models and in vitro cancer cell lines. The experimental studies have suggested that GTPs might have a protective effect against GC due to apoptosis-inducing, antimutagenic, anti-inflammatory, and antioxidant activities. The reason for this discrepancy between the results of experimental studies and this review is unclear. However, there might be a few possible explanations. First is the difference in causative factors between the cancers in humans and animals. It is possible that green tea may be only effective against GC in certain animal species. Second, in in vivo studies, the doses of green tea used in animal models are much higher in comparison to human consumption. Lastly, in the context of GC, there might be a difference in the biological activities of polyphenols as an independent compound rather than green tea taken as a whole. Despite the protective role of an independent compound against the development of cancer, it is possible that the adverse effect of green tea taken as a whole is due to the interactions and complex biological mechanisms of its multiple constituents.

In this review, eight studies have analyzed men and women separately, provided RRs or ORs for each gender[18,22,28-30,32-34]. In these eight studies, men were considered to show no relation at all. Women, however, seemed to show lower risk, though there was no statistically significant difference. It should also be noted that cigarette smoking and alcohol consumption are important confounding factors. For example, in a case-control study by Tsubono et al[40], a protective effect of green tea consumption was observed in women, mostly non-smokers, with an OR of 0.8 and a 90%CI of 0.5-1.3. However, no protective effect was found in men, who were mostly smokers (OR = 1.5, 95%CI: 1.0-2.1). In Asia, tea drinking is commonly associated with cigarette smoking in men. Although the study by Tsubono et al[40] and other studies included in this review tried to correct for smoking, the interaction between these two factors is difficult to assess.

It is noted by Yu et al[31] that among green tea drinkers, the risk of developing GC did not depend on the age when routine tea drinking started. This implied that green tea may disrupt gastric carcinogenesis at the intermediate and late stages. In addition to finding a negative association between green tea drinking and GC risk, Yu et al[31] noted that a lowered risk is observed when the tea was served warm/cold (boiling hot, OR = 1.18, 95%CI: 0.75-1.86; warm/cold, OR = 0.51, 95%CI: 0.29-0.91). This observation was further supported by another case-control study by Deandrea et al[37] (hot, OR = 1.27, 95%CI: 0.85-1.90; lukewarm, OR = 0.19, 95%CI: 0.07-0.49).

In one of the cohort studies, Galanis et al[38] suggested that tea might have a mutagenic effect (OR = 1.5, 95%CI: 0.9-2.3). However, the number of cases in this study was very small, and that may have resulted in the exaggerated risk estimates.

Overall, these data do not seem to suggest a protective effect of green tea on GC. The inconsistent results between the epidemiologic studies may be due to variables, such as differences in tea preparation and consumption, the methods of tea production, the bioavailability of tea compounds, and genetic variation in how the human body responds to tea consumption.

All research findings from tumor cell cultures, animal models, and epidemiological studies have shown the effects of green tea and tea polyphenols in GC prevention. However, this should be confirmed in clinical trials in order to gain more knowledge of the relationship between green tea consumption and GC risks. This review shows that the overall evidence for protective effects of green tea against cancer is inconclusive. Therefore, further epidemiologic studies and clinical trials are warranted. Adequate sample sizes, better descriptions of populations and/or clear definitions of green tea consumption may be required for conclusive studies. It is also important to consider the type of tea or its preparation (e.g., short time vs long brewing time and hot tea vs iced tea) due to the marked impact of these factors on polyphenol content and concentration. It is also important to draw attention on the need of further in-depth studies on the nature and mechanisms of the active green tea compounds, on the bioavailability of the different catechins in human and appropriate dose level to act as functional food. Further epidemiological research, designed specifically to study the effect of green tea on GC, is needed. Because many green tea drinkers brew more than one cup of tea from each batch of dried leaves, in future studies, green tea consumption should be assessed in terms of the amount of active ingredient consumed in a given period. Nevertheless, the in vitro, animal, and epidemiologic studies on the topic of green tea consumption and GC risks offered insightful results worthy of future research on potential cancer prevention in human.

This review has several limitations. First of all, this review only analyzed studies of the Japanese and Chinese population. Green tea is consumed mainly in Asian countries, such as China, Japan, and South Korea, it is not appropriate to generalize the findings in the study and apply it to all populations. The findings and explanations should be explored in further clinical research on a more diverse population. Second, as with most literature reviews, the results should be interpreted with caution because the highest consumption of green tea, lengths of follow-up, and questionnaire were not uniform. Although all publications included in this review adjusted for the consumption of dietary items other than green tea as much as possible, the possibility of residual confounding factors cannot be excluded. Lastly, 15 of the 17 studies investigated did not incorporate H. pylori infection, a strong risk factor for GC, as a confounding factor. The subjects with chronic gastritis caused by H. pylori infection might have limited their consumption of foods and beverages, including green tea. On the other hand, several studies have indicated positive interactions between green tea and H. pylori. EGCG, one of the green tea catechins, has been showed to possess significant protective effect against H. pylori-induced cytotoxicity in gastric epithelial cells via interference of the toll-like receptor 4 signaling induced by H. pylori[48]. Green tea or GTPs have exhibited bactericidal and/or bacteriostatic effects against H. pylori[49,50]. Various components of green tea have been reported to inhibit H. pylori infection as well as H. pylori-induced gastritis and gastric epithelial cell proliferation in animal models[51-53]. Chronic atrophic gastritis (CAG) represents a precancerous lesion of the stomach, and H. pylori infection is known to increase the risk of CAG. Shibata et al[54] conducted a cross-sectional study on 636 subjects livening in a farming village in Japan to examine the relationship among green tea consumption, H. pylori infection, and CAG. H. pylori infection was positively associated with the risk of CAG (OR = 3.73; 95%CI: 2.59-5.36). High green tea consumption (> 10 cups/d) was negatively associated with the risk of CAG, even after adjustment for H. pylori and lifestyle factors associated with green tea consumption (OR = 0.63; 95%CI: 0.43-0.93). The results support the hypothesis that green tea consumption prevents gastric preneoplasia. Hence, future epidemiological studies on green tea and GC risk should consider multivariate analysis on relationship among H. pylori infection sustained by cytotoxin-associated gene A-positive strains, other risk factors, and green tea consumption.


P- Reviewers Franceschi F, Shibata T, Yen HH S- Editor Huang XZ L- Editor A E- Editor Xiong L

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