Effects of anesthetic methods on preserving anti-tumor T-helper polarization following hepatectomy

Figure 3 Statistics of T-helper-cell contents as measured by mRNA expression and cytokine levels. A: mRNA expression of interferon (IFN)-γ, interleukin (IL)-4, IL-17 and FoxP3 on d0, d2 and d7; The mRNA expression levels of IFN-γ on d2 were increased compared to that on d0 (d0 vs d2, ^bP < 0.01), then partly recovered on d7 (d2 vs d7, ^cP <0.05). IL-4, IL-17 and FOXP3 mRNA expression levels showed no significant differences from d0 to d2, whereas mRNA levels of IL-17 and FOXP3 clearly decreased from d2 to d7 (IL-17: d2 vs d7, ^cP < 0.05; Treg: d2 vs d7, ^dP < 0.01); B: Cytokine concentrations of IFN-γ, IL-4, IL-17, IL-10 and transforming growth factor (TGF)-β₁ on d0, d2 and d7 (d0 vs d2: ^aP < 0.05, ^bP < 0.01, respectively).