Agmatine induces gastric protection against ischemic injury by reducing vascular permeability in rats

Figure 5 Photomicrographs representative of angiopoietin-1 immunostaining of gastric sections of the studied groups. A: Sham-operated showing lack of expression of angiopoietin-1 (Ang-1); B: Gastric ischemia reperfusion (I/R) group showing extensive cytoplasmic expression of Ang-1 particularly in areas of congestion and damage; C: Agmatine (AGM) treated group (100 mg/kg, i.p.), with marked attenuation of Ang-1 expression in intact mucosa; D: Wortmannin (15 μg/kg, i.p.) treated group prior to AGM administration abolished the effect of AGM and the expression of Ang-1 is marked (× 20 magnification).