Over-expression of uPA increases risk of liver injury in pAAV-HBV transfected mice

Figure 4 The expression of urokinase plasminogen activator in the livers of in-alb-urokinase plasminogen activator transgenic mice. A: Histology of livers from wild type (WT) mice; B: Histology of livers from in-alb-urokinase plasminogen activator (uPA) mice without doxycycline (Dox) induction; C: Histology of livers from in-alb-uPA mice with Dox induction; D: uPA expression in hepatocytes from from WT mice; E: uPA expression in hepatocytes from in-alb-uPA mice without Dox induction; F: uPA expression in hepatocytes from in-alb-uPA mice with Dox induction. Magnification, × 20.