Dual regulatory role for phosphatase and tensin homolog in specification of intestinal endocrine cell subtypes

doi:10.3748/wjg.v18.i14.1579

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Apr 14, 2012 (publication date) through Jul 26, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 14, 2012; 18(14): 1579-1589
Published online Apr 14, 2012. doi: 10.3748/wjg.v18.i14.1579

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Figure 5 Proposed model for mode of action of epithelial Pten signalling in intestinal epithelial determination and specification of enteroendocrine progenitor cell fate. Epithelial Pten signalling is not essential for maintenance or determination of the secretory precursor. Pten represses specification of glucose-dependent insulinotropic peptide (GIP)-expressing cells by maintaining FoxO1 in the nucleus. GHR: Ghrelin; GRP: Gastrin-releasing peptide; SCT: Secretin; CCK: Cholecystokinin; SST: Somatostatin; GIP: Glucose-dependent insulinotropic peptide; CgA: Chromogranin A.

Citation: Roy SA, Langlois MJ, Carrier JC, Boudreau F, Rivard N, Perreault N. Dual regulatory role for phosphatase and tensin homolog in specification of intestinal endocrine cell subtypes. World J Gastroenterol 2012; 18(14): 1579-1589
URL: https://www.wjgnet.com/1007-9327/full/v18/i14/1579.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i14.1579