Osteopontin expression is associated with hepatopathologic changes in Schistosoma japonicum infected mice

Table 1 Integral optical density of immunostaining in the groups over time

Groups	Staining	Week 6	Week 8	Week 10	Week 14	Week 18
Control group IOD	Osteopontin (× 102)	0.52 ± 0.06	0.55 ± 0.07	0.56 ± 0.06	0.50 ± 0.06	0.50 ± 0.06
	α-SMA (× 102)3	0	0	0	0	0
	TGF-β1 (× 103)	0.20 ± 0.02	0.21 ± 0.02	0.20 ± 0.02	0.20 ± 0.03	0.20 ± 0.02
Model group IOD	Osteopontin (× 102)	6.45 ± 0.5412	10.21 ± 0.8012	31.20 ± 2.8312	6.00 ± 0.5412	2.26 ± 0.2812
	α-SMA (× 102)	0.93 ± 0.092	18.19 ± 1.622	39.13 ± 4.372	30.93 ± 3.872	1.45 ± 0.162
	TGF-β1 (× 103)	2.52 ± 0.2412	4.90 ± 0.5012	9.20 ± 1.2512	3.84 ± 0.3612	0.19 ± 0.022

¹Compared with control group: P < 0.01;

²Compared with previous time point: P < 0.01;

³The staining of α-SMA in the control group was measured, and the result was zero. Results are expressed as the mean IOD (× 10² or × 10³) ± SD. SMA: Smooth muscle actin; IOD: Integral optical density.