Clinicopathological significance of altered Notch signaling in extrahepatic cholangiocarcinoma and gallbladder carcinoma

Figure 3 Delta-like ligand-4 expression in cholangiocarcinomas (immunohistochemistry, × 100). A: Non-neoplastic biliary tissue; B-D: Cholangiocarcinomas. Non-neoplastic biliary epithelial cells (weak) and stromal inflammatory cells (strong) show cytoplasmic staining. Brown-colored expression of delta-like ligand-4 in cholangiocarcinoma cells is located at cytoplasm (B-D), coexisting nuclei (C), and luminal border (D).