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Copyright ©2010 Baishideng.
World J Gastroenterol. Mar 21, 2010; 16(11): 1349-1357
Published online Mar 21, 2010. doi: 10.3748/wjg.v16.i11.1349
Figure 4
Figure 4 Illustration of hypothetical chronic ethanol feeding effects in 26S dysfunction. As a result of phosphorylation deregulation, 20S and 19S binding is altered, which causes 26S dysfunction. Total dephosphorylation of proteasome subunits by phosphatases is prevented by 14-3-3 protein sequestration of the 20S proteasome.