Brief Article
Copyright ©2010 Baishideng.
World J Gastroenterol. Jan 7, 2010; 16(1): 69-75
Published online Jan 7, 2010. doi: 10.3748/wjg.v16.i1.69
Table 1 Characteristics of included trials
Study IDProbioticDesignAllocation concealment/Blinding/Intention-to-treat analysis/Description of withdrawals or dropoutsExp/cont (age, yr)Definition of constipationDuration of interventionIntervention (daily dose)Placebo
Studies in adults
Mollenbrink et al[13] 1994 (Germany)E. coli Nissle 1917RCT, crossoverUnclear/Yes/No/Yes35/35 (18-60)< 2 BM per week4 + 4 wk25 × 109 CFUPlacebo
Koebnick et al[12] 2003 (Germany)L. casei ShirotaRCT, parallelUnclear/Yes/Yes/Yes35/35 (18-70)Not provided4 wk6.5 × 109 CFU, probiotic beveragePlacebo
Yang et al[14] 2008 (China)B. lactis DN-173 010RCT, parallelUnclear/No/Yes/Yes63/63 (25-65, only women)< 3 BM per week; increased stool hardness; non-organic constipation and habitual constipation2 wkFermented milk containing 1.25 × 1010 CFU of probiotic plus yoghurt strainsPlacebo (acidified milk without any ferments or probiotics)
Studies in children
Banaszkiewicz et al[17] 2005 (Poland)L. rhamnosus GGRCT, parallel (computer-generated randomisation list)Yes/Yes/Yes/Yes43/41 (2-16)< 3 BM per week during 14 days for at least 12 wk12 wkLactulose plus LGG 2 × 109 CFULactulose plus placebo
Bu et al[16] 2007 (Taiwan)L. casei rhamnosus Lcr35RCT, parallel (computer-generated randomisation list)Yes/Yes/Yes/Yes18/9 (< 10)< 3 BM per week for > 2 mo plus at least one of the criteria: anal fissures with bleeding due to constipation, faecal soiling, or passage of large and hard stool4 wk8 × 108 CFUPlacebo (starch)