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Copyright ©2009 The WJG Press and Baishideng.
World J Gastroenterol. Sep 7, 2009; 15(33): 4137-4142
Published online Sep 7, 2009. doi: 10.3748/wjg.15.4137
Figure 2
Figure 2 The mechanism of insulin secretion reduction due to glucose toxicity. DNA binding capacity of PDX-1 decreases as a result of oxidative stress caused by hyperglycemia, while insulin biosynthesis and secretion also decrease. Black arrows indicate pathway, grey arrows indicate increase or decrease. PDX-1: Pancreatic duodenal homeobox-1.