Copyright ©2008 The WJG Press and Baishideng. All rights reserved.
World J Gastroenterol. Apr 7, 2008; 14(13): 1969-1971
Published online Apr 7, 2008. doi: 10.3748/wjg.14.1969
Wireless capsule endoscopy
A Mata, J Llach, JM Bordas
A Mata, J Llach, JM Bordas, Digestive Endoscopy Unit, Gastroenterology Service, Imd, Hospital Clinic Barcelona, Barcelona 08036, Spain
Correspondence to: Dr. Josep M Bordas, Digestive Endoscopy Unit, IMD, Hospital Clinic of Barcelona, c/Villarroel 170, Barcelona 08036, Spain. jmbordas@clinic.ub.es
Telephone: +34-93-2275513
Fax: +34-93-2279859
Received: August 11, 2006
Revised: December 12, 2006
Published online: April 7, 2008


Wireless capsule endoscopy is a new technique that allows complete exploration of the small bowel without external wires. Its role has been analyzed in many small bowel diseases such as obscure gastrointestinal bleeding, Crohn’s disease and gastrointestinal polyposis syndromes with promising results. Studies on other pathologies (i.e. small bowel tumour, celiac disease) are under evaluation to define the role of this technique.

Key Words: Wireless capsule endoscopy, Small bowel, Obscure gastrointestinal bleeding, Crohn’s disease, Gastrointestinal polyposis syndrome

Citation: Mata A, Llach J, Bordas J. Wireless capsule endoscopy. World J Gastroenterol 2008; 14(13): 1969-1971

The need and wish to perform endoscopic examination of the small bowel have led to the development of an ingestible miniature camera device capable of obtaining images of the whole small intestine.

Wireless capsule endoscopy is a new type of radiotelemetry video system which is small enough to be swallowed and has no external wires, fiberoptic bundles or cables. It measures 11 mm × 26 mm and weighs 3.7 g. By using a lens of a short focal length, images are obtained as the optical window of the capsule sweeps past the gut wall, without requiring air insufflation of the gut lumen. The capsule is propelled by peristalsis through the gastrointestinal tract and does not require a pushing force to propel it through the bowel. Up to 2002, more than 250 000 capsule explorations had been performed[1], and nowadays this number has increased significantly.

The M2A capsule [Mouth to (2) Anus] initially, and Pillcam SB (Small Bowel) later, from GIVEN (GastroIntestinal Video Endoscopy, Given Imaging Limited, Yoqneam, Israel), and endocapsule from Olympus are the capsules that have been approved for use in the clinical setting. Each capsule contains a lens, light emitting diodes (LEDs), a color camera, 2 batteries, a radio frequency transmitter and an antenna. The camera takes 2 images per second and transmits these by means of radio frequency to a sensor array in a belt placed around the patient’s abdomen and from there to a recording device in the belt. Once the study is completed (between 6 and 8 h), the recording device is removed and the images are downloaded to a computer workstation with software that displays the video images on a computer monitor.

Capsule endoscopy can be performed as an outpatient procedure. Small bowel preparation is still a controversial issue. Some groups used fasting or clear liquids for 10 to 12 h (or even for 24) before the study, although some studies suggest that bowel preparation (with 2 or 4 litres of polyethylene glycol based electrolyte solution or oral sodium phosphate preparation) improves the visualization of the small intestine[23]. A recent Spanish prospective multi-center trial published in abstract form, has shown that all three strategies have similar results[4].

The role of wireless capsule endoscopy has been analyzed in patients with obscure gastrointestinal bleeding and in comparative studies with endoscopic[5] or radiographic methods[6]. Capsule endoscopy has shown a diagnostic yield of 71% compared to 29% of push enteroscopy, in a recent analysis of 7 prospective studies[7]. Another study has shown that the detection rate of capsule endoscopy is higher in patients with ongoing overt bleeding than in those with anemia or prior overt bleeding[8]. In a comparative study with intraoperative enteroscopy, the sensitivity, specificity, positive and negative predictive value of capsule endoscopy were 95%, 75%, 95% and 86%, respectively[9]. For obscure gastrointestinal bleeding, capsule endoscopy has shown better results than radiographic studies, which have a low diagnostic yield in detecting small bowel lesions[610].

Capsule endoscopy has also shown its usefulness in the evaluation of the small intestine in patients with suspected or known Crohn’s disease[11], and is superior to small bowel follow-through[1214], enteroclysis[1516], push enteroscopy[16] and CT enteroclysis[17] for identifying small intestinal disease. The sensitivity and specificity of capsule endoscopy have recently been estimated to be 89.6% and 100%, respectively[18].

However, the diagnostic criteria of capsule endoscopy for Crohn’s disease have not yet been defined. Mucosal breaks and aphthous ulcers or erosions are also seen in asymptomatic healthy volunteers, and small bowel ulcers and strictures have been associated with the use of nonsteroidal anti-inflammatory agents, making it, at times, difficult to differentiate these findings with the presence of a Crohn’s disease[9].

Capsule endoscopy has been performed in patients with gastrointestinal polyposis syndrome, and several studies have suggested that it may be useful in the detection of small bowel polyps[1920]. A comparative prospective study showed that capsule endoscopy can detect more polypoid lesions than small-bowel follow through in these patients[21]. Nevertheless, more prospective studies with longer follow-up are required, to define the role of capsule endoscopy findings in the outcome of patients with gastrointestinal polyposis syndrome.

Capsule endoscopy in the pediatric population and esophageal capsule endoscopy (Pillcam ESO) have shown promising results but larger prospective trials are needed to define their role in these patients.

Other possible indications for capsule endoscopy, such as celiac disease, HIV positive patients with gastrointestinal symptoms, mal-absorption or small bowel transplantation, have not been defined so far, and more prospective trials assessing the use of capsule endoscopy in these groups of patients are still needed.

The main contraindication of performing the capsule endoscopy procedure is the suspicion or knowledge of a gastrointestinal obstruction, stricture or fistula. Other former contraindications such as implanted cardiac pacemakers or other electro-medical devices and patients with swallowing disorders have been excluded since some studies showed no interference between capsule endoscopy and pacemaker or implantable defibrillators functioning[2223] and endoscopic placement of the capsule into the gut[24].

The capsule retention rate varies with the indication of the examination, being reported of 1.5% in patients with obscure gastrointestinal bleeding[25] and 5% in patients with suspected Crohn’s disease[26], who are usually asymptomatic[1025] and may require endoscopic removal or surgery. How to prevent capsule retention has yet o be defined since neither radiologic studies nor the “patency capsule” has shown conclusive results so far. The clinical setting of each patient, as well as some features related to intestinal strictures (previous small bowel surgery, NSAIDs, suspected small bowel Crohn’s disease), have to be analyzed prior to the study. Patients should be informed about the possibility of capsule retention and further treatment.


Peer reviewer: Joerg C Hoffmann, Dr, Medizinische Klinik I, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, Berlin D12200, Germany

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