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Copyright ©2007 Baishideng Publishing Group Co.
World J Gastroenterol. Mar 21, 2007; 13(11): 1715-1722
Published online Mar 21, 2007. doi: 10.3748/wjg.v13.i11.1715
Table 2 Clinical characteristics, thyroid biochemistry, thyroid serology, and HLA-DQ data of patients with both Hashimoto’s thyroiditis and coeliac disease compared to patients with Hashimoto’s thyroiditis only
CharacteristicsPatients with onlyPatients with both coeliac diseaseP
Hashimoto’s thyroiditisand Hashimoto’s thyroirditis
n = 99n = 27
Presence of goiter, n (%)19 (19)4 (15)> 0.05
Presence of autoimmune diseases, n (%)11 (11)7 (26)< 0.01
Thyroid function test
mean ± SD TSH (normal 0.30-4.00 mU/L)24 (± 7.6)16 (± 5.8)< 0.05
mean ± SD Free T4 (normal 11-22 pmol/L)10 (± 4.1)12 (± 5.2)> 0.05
Positive thyroid serological tests, n (%)
Thyroglobulin (TG)35 (36)11 (41)> 0.05
Thyroid peroxidase (TPO)93 (94)25 (92)> 0.05
HLA-DQ 2 and/or -DQ8, n (%)53 (53)27 (100)< 0.01
DQ2 heterozygote30 (30)20 (74)< 0.01
DQ2 homozygote1 (1)3 (11)< 0.01
DQ8 heterozygote22 (22)--
Combined DQ2 & DQ810 (10)4 (15)> 0.05