Liu DY, Gao AN, Tang GD, Yang WY, Qin J, Wu XG, Zhu DC, Wang GN, Liu JJ, Liang ZH. Relationship between onset of peptic ulcer and meteorological factors. World J Gastroenterol 2006; 12(9): 1463-1467
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Da-Yun Liu, Department of Gastro-enterology, Nanning First People’s Hospital, Nannig 530022, Guangxi Zhuang Autonomous Region, China. email@example.com
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Guo-Du Tang, Department of Gastroenterology, First Affiliated Hospital, Guangxi Medical University, Nanning 530012, Guangxi Zhuang Autonomous Region, China
Jiang Qin, Department of Gastroenterology, Hospital of Guangxi Zhuang Autonomous Region, Nanning 530022, Guangxi Zhuang Autonomous Region, China
Zhong-Hui Liang, Department of Gastroenterology, 303 Hospital of Chinese PLA, Nanning 530022, Guangxi Zhuang Autonomous Region, China
ORCID number: $[AuthorORCIDs]
Supported by Guangxi Science and Technology Development Program, No. 9920025
Correspondence to: Da-Yun Liu, Department of Gastro-enterology, Nanning First People’s Hospital, Nannig 530022, Guangxi Zhuang Autonomous Region, China. firstname.lastname@example.org
Received: September 13, 2005 Revised: October 1, 2005 Accepted: October 26, 2005 Published online: March 7, 2006
AIM: To discuss the relationship between onset of peptic ulcer (PU) and meteorological factors (MFs).
METHODS: A total of 24 252 patients were found with active PU in 104 121 samples of gastroscoic examination from 17 hospitals in Nanning from 1992 to 1997. The detectable rate of PU (DRPU) was calculated every month, every ten days and every five days. An analysis of DRPU and MFs was made in the same period of the year. A forecast model based on MFs of the previous month was established. The real and forecast values were tested and verified.
RESULTS: During the 6 years, the DRPU from November to April was 24.4 -28.8%. The peak value (28.8%) was in January. The DRPU from May to October was 20.0 -22.6%, with its low peak (20.0%) in June. The DRPU decreased from winter and spring to summer and autumn (P < 0.005). The correlated coefficient between DRPU and average temperature value was -0.8704, -0.6624, -0.5384 for one month, ten days , five days respectively (P < 0.01). The correlated coefficient between DRPU and average highest temperature value was -0.8000, -0.6470,-0.5167 respectively (P <0.01). The correlated coefficient between DRPU and average lowest temperature value was -0.8091, -0.6617, -0.5384 respectively (P <0.01). The correlated coefficient between DRPU and average dew point temperature was -0.7812, -0.6246, -0.4936 respectively (P <0.01). The correlated coefficient between DRPU and average air pressure value was 0.7320, 0.5777, 0.4579 respectively (P <0.01). The average temperature, average highest and lowest temperature, average air pressure and average dew point temperature value of the previous month, ten days and five days could forecast the onset of PU, with its real and forecast values corresponding to 71.8%, 67.9% and 66.6% respectively.
CONCLUSION: DRPU is closely related with the average temperature, average highest and lowest temperature, average air pressure and average dew point temperature of each month, every ten days and every five days for the same period. When MFs are changed, the human body produces a series of stress actions. A long-term and median-term based medical meteorological forecast of the onset of PU can be made more accurately according to this.
Citation: Liu DY, Gao AN, Tang GD, Yang WY, Qin J, Wu XG, Zhu DC, Wang GN, Liu JJ, Liang ZH. Relationship between onset of peptic ulcer and meteorological factors. World J Gastroenterol 2006; 12(9): 1463-1467
The onset of peptic ulcer (PU) is characterized by seasons, with a high incidence in winter and spring and a low incidence in summer[1-8]. We made a correlated analysis of the relationship between detectable rate of PU (DRPU) from 1992 to 1997 in Nanning and a regressive analysis of the meteorological factors (MFs) in the same period. We found that DRPU was closely related to the seasons and MFs.
MATERIALS AND METHODS
A total of 24 252 patients with active PU were found from 17 hospitals in Nanning from 1992–1997. We then calculated the detectable rate of peptic ulcer in every season, every month, every ten days and every five days. The average value of the 7 MFs was provided by Guangxi Meteorological Observation Station (Table 1).
Average temperature of 1 month, ten days and five days
Average highest temperature of 1 month, ten days and five days
Average lowest temperature of 1 month, ten days and five days
Average air pressure of 1 month, ten days and five days
Average relative humidity of 1 month, ten days and five days
Average dew point temperature of 1 month, ten days and five days
Average total amount of precipitation of 1 month, ten days and five days
We used detectable rate of peptic ulcer (DRPU) to represent the incidence. The detectable rate of a disease was higher than the incidence of its natural multitude, but the variation of both was similar as previous;y described.
(DRPU = number of persons of PU at the same period of time /total number of persons of gastroscopic examination at the same period of time × 100%).
We made a correlated analysis of the DRPU of 1 month, ten days and five days and the 7 MFs in the same period in Nanning. On the basis of it, we carefully chose the meteorological factors. A regressive effect F value test was made for all the independent variables and factors. A multiple linear regressive mathematical model was established for DRPU forecast equation.
Relationship between DRPU and seasons
From 1992 to 1997, the average DRPU in Nanning was 23.29%. The average DRPU from November to April was 24.2-28.8%, with its peak value being 28.8% in January. The average DRPU from May to October was 20.0- 22.6%, with its low peak value being 20.0% in June. The DRPU in winter was 26.48%, 24.98% in spring, 21.10% in summer, and 20.91% in autumn. The seasonal DRPU was χ2 = 343.3004 (P <0.005), indicating that the DRPU differed remarkably in seasons. When the DRPU in winter and spring was compared with that in summer and autumn, χ2 = 327.4435 (P <0.005). When the DRPU in winter was compared with that in spring, summer and autumn, χ2 = 194.0589 (P <0.005). When the DRPU in spring was compared with that in summer and autumn, χ2 = 153.8931 (P <0.005). When the DRPU in summer was compared with that in autumn, χ2 = 0.2744 (P >0.750). The above values showed that the onset of PU was as follows: winter and spring>summer and autumn, winter >spring >summer and autumn. The difference was significant.
Relationship between DRPU AND MFs
We made a further correlated analysis of the DRPU and the 7 MFs in the same period. The results showed that the DRPU was not evidently related to the relative air humidity, but had a negative relation with the average temperature, average highest and lowest temperature, average dew point temperature (P <0.01) and a positive relation with the AAP (P <0.01, Table 2). We found that when the monthly average temperature ≤21°C, the monthly average highest temperature ≤26°C, the monthly average lowest temperature ≤18°C, the monthly average air pressure ≥1007 hPa,the monthly average dew point temperature ≤15°C, the average ten-day temperature ≤19°C, the average ten-day highest temperature ≤24°C, the average ten-day lowest temperature ≤17°C, the average ten-day air pressure≥1008 hPa, the average ten-day dew point temperature ≤14°C, the average five-day temperature ≤17°C, the average five-day highest temperature ≤20°C, the average five-day lowest temperature ≤14°C, the average five-day air pressure≥1008hPa,the average five-day dew point temperature ≤12°C. The correlated analysis of the high onset of DRPU of 1 month, ten days, five days and the above single factors corresponded to 75%-78%. The statistical relation between the factors, can be described by the multivariate linear regression equation:
average error = 2.0051, complex relative coefficient = 0.8129, F month test value = 25.7068, F0.01 = 3.60, F month > Fa, thus P<0.01.
Yten-dayDRPU=62.93681 = 0.34811Tpj + 0.06056Tmax-0.18958Tmin-0.02957P + 0.0004Td, average error = 2.981, complex relative coefficient = 0.664, Ften-day test value = 33.1117, F0.01 = 3.40, F ten- day > Fa, thus P <0.01.
Yfive-dayDRPU=63.49121-0.76259Tpj+0.27832Tmax-0.06448Tmin - 0.03043P + 0.0764Td, average error = 4.0499, complex relative coefficient = 0.5434, Ffive - day test value = 35.6956, F0.01 = 3.07, F five - day >Fa, thus P <0.01.
Establishment of DRPU forecast equation and test of its significance
The correlated analysis of DRPU of 1 month, ten days, five days and 7 MFs of the previous month, ten days and five days indicated that the average temperature, average highest and lowest temperature, average air pressure and average dew point temperature of the previous month were also closely related to the DRPU of the present month, ten days and five days (Table 3). Thus if we made the 5 MFs of the previous month, ten days and five days and the DRPU of the present month , ten days and five days, the factors of three DRPU forecast equations could be established as follows:
Table 3 Correlated analysis of DRPU and 5 MFs of the previous month, ten days, and five days.
Average monthly temperature
Average ten-day temperature
Average five-day temperature
Average monthly highest temperature
Average ten-day highest temperature
Average five-day highest temperature
Average monthly lowest temperature
Average ten-day lowest temperature
Average five-day lowest temperature
Average monthly air pressure
Average ten-day air pressure
Average five-day air pressure
Average monthly dew point temperature
Average ten-day dew point temperature
Average five-day dew point temperature
The above analysis showed that the 3 forecast equations had good regressive effect. The real test values of the three forecast equations were 71.8%, 67.9% and 66.6%, respectively.
Tmax+2.97619Tmin+0.37869P-0.29906Td, average error=2.1138, complex relative coefficient=0.7907, F month test value= 21.6887, F0.01 =3.60, F month >Fa, thus P<0.01.
0.09075Tmin+0.07605P-0.04132Td, average error=3.0625, complex relative coefficient=0.6383, F ten-day test value= 28.7387, F0.01=3.40, F ten- day>Fa, thus P<0.01.
Yfive-dayDRPU=-0.826-0.13995Tpj-0.00568Tmax-0.24365Tmin+0.04104P+0.00342Td, average error=4.0629, complex relative coefficient=0.5362, Ffive-day test value=34.2292, F0.01=3.07, F five -day> Fa, thus P<0.01.
It is generally believed that the occurrence of PU is due to the effect of unbalance between the attacking factors such as hydrochloric acid in gastric juice and the defending factors of the mucosa. Helicobacter pylori (H pylori) infection is also an important cause of PU[10-25]. Treatment of hydrochloric acid in gastric juice and anti- pylorus bacteria can protect stomach duodenum mucosa, yet the occurrence of PU still has remarkable seasonal variations . Therefore the influence of variations of meteorological factors on PU must be considered. Research has shown that the occurrence of PU in winter is related to the higher air pressure and temperature . The high occurrence of PU in summer is likely to be related to the lower air pressure. Our study also confirmed the seasonal onset of PU. Analysis of MFs has shown that special attention should be paid to PU patients in winter and spring . Since increased air pressure and dry air result from the cold air, temperature plays a more important role . When these meteorological factors are changed violently, a series of stress action take place, causing endocrinopathy. It was reported that severe cold and changing temperature result in acute stress actions in human body, causing excitation of sympathetic nerve and adrenal gland marrow and rapid secretion of adrenaline and noradrenalin. Animal tests also showed that mouse hypertensin II is much higher compared with acute stress action, sub-acute stress action and other chronic stress action . When human body is stimulated by acute or slow stress action, hypertensin II in plasma increases remarkably. Cold stimulation and oxygen shortage stimulation may accelerate secretion of endothelin. Adrenaline, hypertensin II and endothelin may cause contraction of duodenal mucosa and blood vessel, leading to mucosa blood flow fall and mucosa damage [29-30]. Stomach blood insufficiency may also stimulate the rise of endothelin . Kou and Li  reported that the stomach mucosa blood vessels contract immediately after injection of endothelin. It has also been verified that plasma endothelin density of PU patients is related to the degree of damaged stomach mucosa . Stress action may lessen the stomach mucosa mucus, and lower the stomach mucosa’s protective function . Furthermore cold stress action may lessen the secretion of inhibitable growth factors [34,35]. When the secretion of the inhibitable growth factors becomes less, secretion of hydrochloric acid increases in gastric juice. Meanwhile endothelin can accelerate the secretion of hydrochloric acid in gastric juice. It has been verified that when endothelin is injected, plasma progastrin increases progressively . When blood supply is insufficient in the duodenal mucosa and the protection barrier is damaged due to insufficient oxygen, the increase of hydrochloric acid in gastric juice accelerates the occurrence is of PU. Moreover, cold weather decreases human body’s immunity function . Some Japanese experts pointed out that from December to March, the number of human body outer lymph cells and B lymph cells is small , indicating lower body cell immunity and body fluid immunity function. Therefore when the temperature stimulates human body, adrenocorticotropin increases its secretion and hypertensin II rises, restraining the body immunity function and causing immunity functional disorder, and making it easy for the duodenal mucosa to be attacked by H pylori, which destroys the stomach mucosa protection barrier, impairs the stomach mucosa and then restrains secretion of inhibitable growth factors and stimulates secretion of progastrin[12-25].
In conclusion, acute, sub-acute and slow stresses on the human body are likely the cause of PU in winter and spring.
The other persons who joined us in the study were Yi Wu from the First Affiliated Hospital, Guangxi Medical University, Gui-Yan Chen from the Affiliated Tumor Hospital to Guangxi Medical University, Yue-Ping Xie from First Municipal People’s Hospital of Nanning, Dong-Xing Su and Rong-Ying Zhang from Second Municipal People’s Hospital of Nanning, Zhen-Hua He and Zhi-Guang Yi from First Affiliated Hospital to Guangxi Traditional Chinese Medicine College, Bo-Qang Tan and Dong-Ying Chen from Second Affiliated Hospital to Guangxi Traditional Chinese Medicine College, Wang Hui-Fang from People’s Hospital of Nanning Prefecture, Xiao-Liang Chen from Third Municipal People’s Hospital of Nanning, Yi Liao from fourth Municipal People’s Hospital of Nanning, Yin-Qin Wu and Yan Cai from Nanning Red Cross Hospital, Zheng-Hua Pan from Nanning Railway Hospital, Li-Mei Wang from Nanning Hospital of Traditional Chinese Medicine, Yu-Qun Chen from Nanning Maternity and Child-care Hospital, Guo-Gun Zeng from Hospital of Guangxi Armed Police, Li-Yun Yi from Guangxi Mao Qiao Hospital.
Co-firs-tauthor: Da-Yun Liu,An-Ning Gao and Guo-Du Tang
S- Editor Wang J L- Editor Wang XL L- Editor Zhang Y
Lu XH, Yu ZL, Wang HZ. Epidemiological survey of peptic ulcer disease in Beijing area: Endoscopic analysis of 358644 cases.Chin J Dig. 1996;16:152-154.
Zu Y, Zhe L, Zheng J. Clinical epidemiologic investigation of peptic ulcer.Chin J New Gastroenterol. 1996;4:609-610.
Chen GJ, Chen LJ, Ni SH. Investigation on the correlation between the found rate of peptic ulcer and the meteorological factors in Zhanjiang area.Modern Preventive Medicine. 1998;25:36-38.
Quan HB, Wu ZG, Zhou NM. The clinical epidemiology of 4426 cases of peptic ulcer at the zhongshan prefecture.Chin J New Gastroenterol. 1997;5:737-738.
Mo HS. Clinical epidemiology of 3088 patients with peptic ulcer.Chin J New Gastroenterol. 1996;4:151-152.
Qin CP. The epidemiology of peptic ulcers at the Liuzhou prefecture.Neijing. 1996;13:22-24.
Hunan Research on peptic ulcer(He FQ, Xie JC, Pu XQ). A survey of 5025 cases of peptic ulcer.Henan Yixueyuan Xuebao. 1984;9:171-174.
Zhang ST, Yu ZL, Yang XW, Ju XS, Wang HY, WM . Relationship between onset of peptic ulcer and variations of meteorological factors.Chin J Dig Endosc. 1997;14:225-228.
Jiayou Huang. Analysis and Forecast Methods of Meteorological Statistics,Di’erban. Beijing: Meteorological Publishing House 2000; 1-86.
Hirakawa T. Diagnosis of Helicobacter pylori with emphasis on endoscopic diagnosis.World J Gastroenterol. 1998;4:56.
Nomura A, Stemmermann GN, Chyou PH, Perez-Perez GI, Blaser MJ. Helicobacter pylori infection and the risk for duodenal and gastric ulceration.Ann Intern Med. 1994;120:977-981.
Liang HJ, Gao JH, Liu WW. Longterm effects of concentrated Helicobacter pylori culture supernatant on gastric mucosa of rats.Shijie Huaren Xiaohuo Zazhi. 1999;7:861-863.
Yu CQ, Zou QM, Xic QH. The relationship between Helicobacter pylori VacA infection and digestive disease.Shijie Huaren Xiaohuo Zazhi. 1999;7:439.
Li ZX, Zhang WD, Zhou DY. Relationship between Helicobacter pylori and duodenal ulcer.Chin J New Gastroenterol. 1996;4:153-155.
Zhu XL, Liu RX, Li G. Changes of ammonia in gastric juice of patients With Helicobatter pylori infection.Chin J New Gastroenterol. 1997;5:21-22.
Chen JP, Xu CP, Liu FX. Ultrastructural study of gastric mucosa preand post-eradication of Helicobacter pylori infection.Chin J New Gastroenterol. 1997;5:19-20.
Zhang YL, Lai ZS, Wang JD. Helicobacter pylori associated gastric mucosal inflammation and histopathological assessment.Natl Med J China. 2001;81:811-815.
Wang CD, Huang HH, Chen YL. Effect of Helicobacter pylori infection on antral G and D cells in patients with active duodenal ulcer.Shije Huaren Xiaohua Zazhi. 2000;8:847-850.
Zheng CQ, Li YQ Zhou Z, Jiang WG, Liu DJ. Studies on SS content and D cell ultrastructure in duodenal ulcer disease with Hp-associated antral gastritis.Chin J Dig. 1998;18:281-283.
Nie ZH, Zheng WY. Guo RB. Effect of EGF on peptic ulcer: relationship between H. Pylori and gastric mucosal inflammation.Shijie Huaren Xiaohuo Zazhi. 1998;6:600-602.
Peng ZS, Liang ZC, Liu MC. Studies on gastric epithelial cell proliferation and apoptosis in Hp associated gastric ulcer.Shijie Huaren Xiaohua Zazhi. 1999;7:218-219.
Miao K, Sun L, Laura H. Influence of Helicobacter pylori lipopolysaccharide on the function of enterochromaffin-like cells in vitro.Chin J lnterm Med. 1999;38:670-672.
Wang XZ, Li B, Lin GZ. Comparison of triple therapy with lansoprazole or famotidine for Helicobacter pylor-associated duodenal ulcer.Shijie Huanren Xiaohua Zazhi. 1998;6:99-100.
Rudi J, Rudy A, Maiwald M, Kuck D, Sieg A, Stremmel W. Direct determination of Helicobacter pylori vacA genotypes and cagA gene in gastric biopsies and relationship to gastrointestinal diseases.Am J Gastroenterol. 1999;94:1525-1531.
Kohda K, Tanaka K, Aiba Y, Yasuda M, Miwa T, Koga Y. Role of apoptosis induced by Helicobacter pylori infection in the development of duodenal ulcer.Gut. 1999;44:456-462.
Zhang JJ, Lian ZC, Xu GS. Digestive tract of physiology and pathologicphysiology, Diyiban. Guangzhou: Guangdong Keji Chubanshe 1997; 1483.
Lianbo Xia. Medical Meteorology-The Influence of Weather and Climate Over Health, Diyiban. Shanghai: Knowledge Publishing House 1984; 25-28.
Gang Yang. Endocrinophysiology and Pathologicphysiology, Di'erban. Tiangjin: Tianjin Kexue Jishu Chubanshe 2000; 771,782-793, 905-926.
Zhang H, Wang H, Kuang J. Effect of cold stimulation on Plasma Endothelin and Hemorheology in Experimental Ischemic Myocardial Rabbits.Basic Medical and Clinic. 1998;18:69-71.
Michida T, Kawano S, Masuda E, Kobayashi I, Nishimura Y, Tsujii M, Hayashi N, Takei Y, Tsuji S, Nagano K. Role of endothelin 1 in hemorrhagic shock-induced gastric mucosal injury in rats.Gastroenterology. 1994;106:988-993.
Kou G, Li ZS. Endothelin and Gastric Mucosal lijury.Guowai Yixue Xiaohua Jiben Fence. 2000;20:8-11.
Masuda E, Kawano S, Michida T, Tsuji S, Nagano K, Fusamoto H, Kamada T. Plasma and gastric mucosal endothelin-1 concentrations in patients with peptic ulcer.Dig Dis Sci. 1997;42:314-318.