Value of mink vomit model in study of anti-emetic drugs

doi:10.3748/wjg.v12.i8.1300

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 12, Issue 8

This Article

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (1865)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-1) series, Tables (1-2) series.

Item

Count

PDF

262

HTML

1364

Figures (1-1)

132

Tables (1-2)

107

Sum=1865

Feb 28, 2006 (publication date) through Apr 19, 2024

Times Cited of This Article

Times Cited (13)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Rapid Communication

World J Gastroenterol. Feb 28, 2006; 12(8): 1300-1302
Published online Feb 28, 2006. doi: 10.3748/wjg.v12.i8.1300

Table 2 Effects of ondansetron or metoclopramide on emesis induced by cisplatin or apomorphine in minks (mean±SD, n=6)

Emetogens	Dose (mg/kg)	Anti-emetics	Dose (mg/kg)	Latency (min)	Retching (n)	Emesis (n)
Cisplatin	7.5	NS		92.0 ± 21	91.5 ± 37	12 ±
Cisplatin	7.5	Ondansetron	2	143.8 ± 80	47.3 ± 41	5.3 ± 5^a
Apomorphine	1.6	NS		39.4 ± 36	28.5 ± 16	5.3 ± 1.9
Apomorphine	1.6	Metoclopramide	4	-a	1.3 ± 3^b	0.3 ± 0.8^d

^aP = 0.018, t = 2.93 vs vehicle-pretreated cisplatin group; ^bP = 0.0022, t’ = 4.08, ^dP = 0.003, t’ = 5.94 vs vehicle-pretreated apomorphine group; -a: only 1 monk had retching and vomiting.

Citation: Zhang F, Wang L, Yang ZH, Liu ZT, Yue W. Value of mink vomit model in study of anti-emetic drugs. World J Gastroenterol 2006; 12(8): 1300-1302
URL: https://www.wjgnet.com/1007-9327/full/v12/i8/1300.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i8.1300