Effects of dietary intake and genetic factors on hypermethylation of the hMLH1 gene promoter in gastric cancer

Table 3 Interaction between amount of cigarette smoking and alco-hol intake, and hMLH1 gene promoter hypermethylation in gastric cancer

	OR1 (95%CI2)
	Cases without	Cases with
	hMLH1 promoter	hMLH1 promoter
	hypermethylation	hypermethylation
	vs controls	vs controls
Cumulative smoking
0	1	1
1 – 15	0.96 (0.38 – 2.41)	0.86 (0.22 – 3.41)
16 – 34	0.92 (0.44 – 1.93)	0.75 (0.24 – 2.38)
35 –	0.39a (0.16 – 0.93)	3.17a (1.20 – 8.42)
χ2trend	1.202	6.344a
Ethanol uptake
per week (g/wk)
0	1	1
≤ 280	0.58 (0.29 – 1.14)	1.35 (0.51 – 3.55)
≥ 281	0.68 (0.30 – 1.53)	3.94a (1.21 – 12.80)
χ2trend	0.83	5.419a

¹Odds ratio estimated using a conditional logistic analysis.

²Confidence interval.

^aP < 0.05 vs others.