Gastric Cancer
Copyright ©2005 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 7, 2005; 11(21): 3189-3196
Published online Jun 7, 2005. doi: 10.3748/wjg.v11.i21.3189
Quality of life in gastric cancer
Ad A. Kaptein, Satoshi Morita, Junichi Sakamoto
Ad A. Kaptein, Psychology Unit, Leiden University Medical Center (LUMC), Leiden, The Netherlands
Satoshi Morita, Department of Epidemiology and Health Care Research, Kyoto University Graduate School of Medicine, Kyoto, Japan
Junichi Sakamoto, Department of Epidemiological and Clinical Research Information Management, Kyoto University Graduate School of Medicine, Kyoto, Japan
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Ad A. Kaptein, Psychology Unit, Leiden University Medical Center (LUMC), PO Box 9555, 2300 RB Leiden, The Netherlands. a.a.kaptein@lumc.nl
Telephone: +31-71-5275237 Fax: +31-71-5273669
Received: May 7, 2004
Revised: May 8, 2004
Accepted: July 9, 2004
Published online: June 7, 2005

Abstract

AIM: To summarize the empirical research on assessing quality of life (QOL) in patients with gastric carcinoma.

METHODS: Literature searches were conducted in MedLine from 1966 to February 2004.

RESULTS: Twenty-six studies were identified. QOL was used as an outcome measure in virtually all identified studies, such as those examining the effects of gastric cancer and various medical or surgical treatments in the patients. QOL was assessed mainly with generic measures; the social dimensions of QOL were largely neglected. The lack of gastric cancer-specific QOL measures hampers QOL research up to now. The gastric cancer-specific EORTC-QLQ-STO22 and the FACT-Ga are important additions to the arsenal of disease-specific QOL measures. In most of the studies, the label QOL is used for questionnaires, which only assess symptoms or performance status, or are physician-reported rather than patient-reported outcomes.

CONCLUSION: QOL in patients with gastric cancer deserves more systematic studies, especially as one of the outcome measures in randomized clinical trials. Results of studies that include QOL in patients with gastric cancer should be applied in clinical care, which aims at improving QOL of these patients.

Key Words: Quality of life, Gastric cancer


Citation: Kaptein AA, Morita S, Sakamoto J. Quality of life in gastric cancer. World J Gastroenterol 2005; 11(21): 3189-3196
INTRODUCTION

‘So, Dormidont Tikhonovich, I came to ask you to come down and give me a gastrointestinal examination. Any day that suits you, we’ll arrange it.’ She looked grey and her voice faltered. Oreshchenkov watched her steadily, his glance never wavering and his angular eyebrows expressing not one millimetre of surprise. ‘Of course, Ludmila Afanasyevna. We shall arrange the day. However, I should like you to explain what your symptoms are, and what you think about them yourself.’‘I’ll tell you my symptoms right away, but as for what I think about them-well, you know, I try not to think about them. That is to say, I think about them all too much, and now I’ve begun not sleeping at nights. The best thing would be if I knew nothing! I’m serious. You decide whether I’m to go into hospital or not and I’ll go, but I don’t want to know the details. If I’m to have an operation I would rather not know the diagnosis, otherwise I’ll be thinking the whole time during the operation, “What on earth are they doing to me now? What are they taking out now?” Do you understand?[1]

In medical care for patients with (gastric) cancer, the 5-year survival is a crucial outcome. At the same time, quantity of survival is increasingly supplemented by data on quality of survival. In this journal, for example, 15 articles that are retrieved under the search heading ‘gastric cancer and quality of life’ have all been published since 1998. Defining quality of life (QOL) is a complex matter, a universally accepted definition does not exist[2]. Schipper et al[3], proposed “the functional effect of an illness and its consequent therapy upon a patient, as perceived by the patient”. Functional effects usually are separated into three categories: physiological, psychological, and social. QOL, therefore, is a multidimensional construct. In a patient with gastric cancer, a physiological effect might be nausea or problems with swallowing, and a psychological effect could be depression, and a social effect might be withdrawal due to embarrassment about being ill. Sometimes economic effects are also discussed in the context of functional effects of illness[2]. There is also a discussion about spiritual effect of illness[4]. In general, however, the triad ‘physiological’, ‘psychological’, and ‘social’ effects is considered to represent the QOL.

QOL can be assessed using generic or disease-specific measures. Generic measures are used in every conceivable disease or disorder. Scores on those measures allow comparisons between groups of patients with an identical diagnosis but with different grades of severity or in different settings or countries, between two groups of patients with different diseases, or between a group of patients with a disease and persons without disease. Disease-specific measures have been designed to particularly assess QOL of patients with a specific disease. For example, in patients with Crohn’s disease, the IBS-QOL is a disease-specific QOL measure[5], and the SF-36 is a generic QOL measure[6]. Cancer-generic measures (e.g., EORTC-QLQ-C30) assess QOL across various diagnostic cancer categories[7]. EORTC and FACIT have developed a wide range of questionnaires that assess QOL for various specific cancer types (visit http://www.eortc.be and http://www.facit.org/qlist.aspx )[8].

QOL is not a ‘soft’ measure. If surgical technique A results in a similar 5-year survival as surgical technique B, differences in aspects of QOL, such as nausea, depression, and embarrassment, may determine which surgical technique is preferable. This view has been previously described in the area of gastroenterology, e.g., in functional bowel syndrome[9]. In gastric cancer, however, the topic of QOL is virtually unexplored. Recent reviews of gastric cancer in major journals do not mention QOL at all, let alone discussing QOL in the context of one of the outcome measures[10]. This is in sharp contrast with the area of QOL and, for instance, breast cancer. In this area, QOL is assessed with well-developed and validated measures, and QOL is a major outcome variable, which also influences the choice of medical management[11].

In this paper, our aim is to review all empirical studies on the topic of gastric cancer and QOL, with a view to outline strengths and weaknesses in the empirical material available, and to suggest some future research avenues.

MATERIALS AND METHODS

Literature searches were conducted in MedLine from 1966 to February 2004, with Mesh headings ‘gastric cancer’ and ‘quality of life’, and ‘gastric cancer’ and ‘psychology’. References in the retrieved papers were studied meticulously, and ‘snowballing’ produced additional papers. Only papers in English were selected. Excluded were studies on mixed diagnostic groupings, i.e., patients with gastric cancer were part of a large group of patients with various other types of (usually gastrointestinal) cancer, or that dealt with QOL, but only symptoms were measured, where only one of the three core QOL domains was assessed, or where QOL was not a patient-reported outcome but merely a physician-reported outcome[12]. Given the high prevalence of gastric cancer in Japan, an additional literature search was carried out in Ichushi-WEB, one of the largest literature searches in Japan of original papers, case reports and minutes of meetings held in Japan, which can be searched.

Empirical studies were analyzed according to first author and year of publication, country where the study was conducted, diagnosis or diagnostic category, study objective(s), number of patients and sociodemographic details, measure(s) used to assess QOL, results, domains in the QOL assessment, type of scale (generic, cancer-generic, or disease-specific), and remarks (on weaknesses in the study). The results are summarized in Table 1.

Table 1 Summary of the 26 studies on QOL in gastric cancer.
First author, yrCountryDiagnosisObjective(s)N patients, age in yr, ; ♀QOL measure(s)Result(s) regarding QOLDomainsType(s) of questionnairesRemarks
Adachi, 1999[15]JapanEarly gastric cancerEvaluate QOL after laparoscopic assisted vs conventional gastrectomy76-64±10 (mean) 44; ♀32Mailed questionnaire, 24 items (cf. Korenaga 1992[28]) ‘QOL’, dumping syndromeLaparascopic-assisted gastrectomy patients: QOL ↑PHY: eating PSY: fatigue, pain SOC: –Gastric-Spec-H, C-GenNo Bonferroni correction for multiple testing, no social dimension in QOL, non- randomized design
Anderson, 1995[16]ScotlandAdenocarcinoma of the stomachExamine relief of symptoms after surgical treatment57-67 (median); 48-88 (range) 35; ♀22Symptom list scored via interviewsAfter surgery: symptoms ↓PHY: dysphagia, dyspepsia PSY: pain SOC: –Gastric-Spec-H-
Buhl, 1990[17]GermanyGastric cancerEvaluate QOL after subtotal vs total gastrectomy ♂-♀: n.r.89-61±13(mean) disease-specificTroidl questionnaire: between groups and socio-personal dimensions; psychological problems (Horowitz scale; Zerrsen scale)No significant differences between groupsPHY: eating PSY: intrusion, avoidance, fatigue, pain, depression SOC: –Disease specific, HOf the six measures, only QOL; no correlation between objective and subjective measures; no social dimension
Davies,1998[18]UKGastric carcinomaEvaluate QOL after subtotal vs total gastrectomy47 69 (median) 33-84 (range) 27; ♀20ADL, HAD, RSCL, TroidlQOL ↑ in subtotal gastrectomyFull blown QOL: PHY, PSY, SOCCancer generic,gastric cancer specific,HNon-randomized design
Eguchi,2003[19]JapanGastric cancerExamine effects of docetaxel+5FU on survival and QOL5 64 (mean) 57-70 (range) 4 ; ♀1EORTC-QOL-C30QOL ↑ PSY, SOCFull blown QOL: PHY,Cancer genericQOL is secondary endpoint
Fuchs, 1995[20]GermanyGastric cancerQOL as one of the outcome measures in two surgical procedures (JIP vs RYP)120 58 (mean)78; ♀42Spitzer and Visick questionnaires:both patient scoredNo differencesbetween proceduresPHY: functional status PSY: activities SOC: supportCancer genericInteresting:Spitzer and Visick were patient scored; randomized design
Hoffman, 1998[21]SwedenGastric cancerAssess relevance of Clinical Benefit Response (CBR) criteria for effectiveness of chemotherapy61 63 (median) 40-75 (range)-♀: n.r.EORTC-QOL-C30, QLQ-C13 items, symptoms → translated into CBRPatients’ views, doctors’ views and CBR: similar resultsFull blown QOL: PHY, PSY, SOCCancer generic,gastric cancer specific, HCBR reflects combination of objective and subjective changes; retrospective design
Hoksch, 2002[22]GermanyGastric cancerAssess QOL after gastrectomy, with different types of reconstruction (IPP, IPP7, IPP15)41-59 (mean) 25-74 (range)20; ♀21EORTC-QLQ-C30, food consumptionNo major differences,except for ‘global health status’ (IPP15↑)Full blown QOL: PHY, PSY, SOCCancer generic,gastric cancer specific, HProspective randomized trial; QOL was target of trial
Horváth, 2001[23]HungaryTotal gastrectomyAssess QOL (aboral pouch, R-and-Y)46 60 (median) 26-80 (range) 24; ♀22GIQLIIn aboral pouch: QOL ↑Full blown QOL: PHY, PSY, SOCDisease specific for gastrointestinal disorders in generalRandomized controlled study
Ishihara, 1999[24]JapanStomach cancerEvaluate QOL and ADL≥2 yr after total gastrectomy51 67 (mean) 39-82 (range)32; ♀19QLI, dumping symptomsQOL ↓PHY: physical strength PSY: fatigue, anxiety SOC: –Cancer generic,H; gastric cancer specific, HValidity?
Jentschura, 1997[25]GermanyGastric carcinomaEffects of subtotal vs total gastrectomy on QOL195 61 (mean)122; ♀73GIQLISubtotal gastrectomy better QOLFull blown QOL: PHY, PSY, SOCQuestionnaire designed for assessing gastrointestinal symptomsNon-randomized design
Kalmár,2001[26]HungaryAdenocarcinomaof the stomachAboral pouch vs total gastrectomy re QOL40 -60±-919;♀21GIQLIPouch better QOLFull blown QOL: PHY, PSY, SOCSee Jentschura 1997[25]Randomized trial; see also Horváth et al[23], 2001
Kono, 2003[27]JapanEarly gastric cancerR -en- Y vs pouch re QOL47 -66±11 32;♀15GSRS and symptomsPouch better QOL (at 3 mo; not at 12 or 48 mo)PHY: reflux PSY: pain SOC: –Disease specific for gastrointestinal disorders in generalRandomized controlled study; author modified GSRS; no social dimension
Korenaga, 1992[28]JapanGastric cancerRetrospective QOL assessment after gastrectomy150 ≤59:89 ≥60:6197; ♀53QOL: symptoms via interview (cf. Adachi et al[15], 1999 )Food tolerance ↓ Appetite ↓PHY: eating PSY: appetite SOC: – See Adachi et al[15],1999Gastric cancer specific, HQOL?
de Liaňo,2003[29]SpainGastric cancerAssess QOL after curative resection54 67 (mean) 41-89 (range) 36; ♀18EORTC-QLQ-C30, and disease-specific questionsQOL-social ↓Full blown QOL: PHY, PSY, SOCCancer generic and disease specificNo correlation between tumor stage and QOL
Liedman,2001[30]SwedenGastric cancerTo examine relations between clinical nutritional parameters and QOL after gastrectomy32 66 (mean) 41-82 (range)21; ♀11BSS, CPRS, GSRS (gastric symptoms), MACL, SIP, SSIAMStrong correlations between change in body composition and QOLFull blown QOL: PHY, PSY, SOCGeneric and gastric symptoms specific-
Miyoshi, 2001[31]JapanGastric cancerCompare long- term results regarding symptoms and nutritional status in patients with/without pouch34 -63±1222; ♀12GSRS and symptomsPouch: QOL ↑PHY: pain, reflux PSY: eating SOC: –Gastric symptoms questionnaireQOL?
Nakano, 1999[32]JapanUnresectable gastric cancer and postoperative gastric cancerEffects of Lentinan on survival and QOL45 -64 (mean) 45-75 (range)34;♀11Homemade QOL questionnaireLentinan: QOL↑Full blown QOL: PHY, PSY, SOCDisease specific questionnaire (14 items)Validity of QOL scale?
Shiraishi, 2002[33]JapanGastrectomyCompare QOL among three surgical techniques51 -63±1137;♀14Adachi 1999[15] questionnaire: 24 items on symptomsGastric tube reconstruction: best QOL; no other differences in QOL between techniquesFull blown QOL: PHY, PSY, SOCGastric cancer specific, HValidity? See Adachi 1999[15]
Svedlund, 1999[34] (see also Svedlund, 1997[35])SwedenSubtotal vs total gastrectomyExamine impact of gastrectomy procedures on QOL64 67 (mean)39;♀25BSS, CPRS, EDS, GSRS, MACL, SIP, SSIAMPhysical QOL categories negatively impairedFull blown QOL: PHY, PSY, SOCDisease generic; gastric symptoms specific; gastric cancer specific symptomsOne of the few follow-up studies in this area; prospective randomized trial; psychiatric focus
Svedlund,1996[36]SwedenGastrectomyQOL before gastrectomy103 72 (mean)60; ♀43BSS, MACL, SIPPatients vs healthy controls: QOL ↓; 25% report functional limitationsFull blown QOL: PHY, PSY, SOCGeneric and symptom specificComparison of gastric cancer patients with other patient groups
Thybusch-Bernhardt, 1999[37]GermanyTotal gastrectomy and D2 lymphadenectomyEffects on QOL following surgical procedures62 63 (mean) 32-80 (range) 40;♀22EORTC-QOL-C30 and gastric cancer moduleNo major differences in QOL between proceduresFull blown QOL: PHY, PSY, SOCCancer generic; gastric cancer specific, HNon-randomized design
Troidl,1987[38]GermanyGastric cancerEsophago-jejunostomy vs Hunt-Lawrence-Rodino pouch on QOL38 -69 (median) 41-75 (range)23; ♀15Troidl questionnaire: 11 items, “disease specific” and “socio-personal”HLR: QOL ↑PHY: daily activities PSY: fatigue SOC: –Disease specific symptoms, HRandomized trial, no social dimension; validity?
Vickery, 2001[39]France,Germany,Spain,UKGastric cancerDevelop disease- specific QOL questionnaire115 66 (mean) 35-97 (range) 75;♀4022-item EORTC-QLQ-STO225 scales, 4 itemsFull blown QOL: PHY, PSY, SOCDisease specific QOL questionnaireFirst formal disease-specific QOL instrument for gastric cancer
Yamaoka, 1998[40]JapanGastrectomyExamine effects of personality on HRQOL207 -57 (mean) 32-83 (range) 140;♀67EPQ, HRQOL-20Relationships between personality and QOLFull blown QOL: PHY, PSY, SOCDisease generic scale, H; generic questionnaireInteresting theoretical extension: examine personality factors
Zieren,1998[41]GermanyGastric carcinomaCompare Spitzer with EORTC-QOL-C36, after resection71 59 (mean) 27-77 (range) 47; ♀24EORTC-QLQ-C36Physical functioning most limitedFull blown QOL: PHY, PSY, SOCCancer generic questionnaire-
RESULTS

The literature searches plus extensive and detailed studying of the references resulted in 26 studies that fitted our selection criteria (Table 1).

The year 1987 saw the publication of the first empirical paper on QOL in gastric cancer: Troidl and colleagues published their QOL questionnaire, which seems to have been very useful to quite a few researchers later[38]. The 26 studies pertain to a 17-year period; on average, every 8 mo a study was published. It is rather striking to note that we did not find a paper from North America; 17 papers are from European countries and 9 from Japan. Since our focus is on QOL assessment, we did not specify in great detail diagnosis, diagnostic categories, surgical or other medical procedures. Virtually all studies aimed at assessing QOL as an outcome for medical care. The number of patients in the studies ranged from 5 to 207.

A great variety of QOL instruments are reported in the 26 studies. The column in Table 1, which summarizes the QOL questionnaires, illustrates the relatively new status of QOL research in gastric cancer. Homemade questionnaires, questionnaires that assess performance status, and questionnaires not designed specifically for (gastric) cancer patients, are applied quite frequently. The increasing use of the cancer-specific, but gastric cancer generic EORTC-QLQ-C30 questionnaire is a positive development. This is a measure with adequate psychometric characteristics and it allows comparisons between gastric cancer patients with other categories of cancer patients. The majority of studies cover physical and psychological functioning; social functioning is assessed somewhat less frequently. The authors of the reviewed papers sometimes label questionnaires as assessing ‘quality of life’, where they are in fact physician-reported scores (e.g., the Karnofsky, Spitzer, and Visick questionnaires) which by definition is not quality of life.

The search in Ichushi-WEB produced 119 original papers and 94 original case reports hits. Of the 119 studies, 8 assessed QOL of patients using a QOL questionnaire. Almost all questionnaires were homemade ones, and only three studies used a cancer-specific core questionnaire developed in Japan by standardized psychometric testing[42]. The three studies were all published in the Japanese Journal of Cancer Chemotherapy, in Japanese[43-45].

DISCUSSION

QOL in patients with gastric cancer is increasingly added as an outcome measure in clinical research. Over half of the studies in the review are recent (>1998 or later) studies. This development is in line with other areas in medicine[46,47]. In most of the reviewed studies, QOL was used to evaluate the effects of medical treatment, usually after some form of surgery or chemotherapy. So far, there are no studies on prediction of QOL or on determinants of QOL in the area of gastric cancer. Another finding of our review reflects the coming of age of QOL research in gastric cancer: physiological functioning is included in virtually all studies, psychological functioning is included in about half of the studies, and social functioning is hardly included at all. Clearly, future research must take this result into account. Using symptom scores as a measure of QOL is not appropriate any longer-it reflects a rather strict biomedical model of thinking, while QOL research aims to further develop a biopsychosocial model of medicine[48].

Using only traditional outcome criteria such as response rate or objective tumor regression, for example in patients with solid tumors of the lung, colon or breast, is hardly valid any more in modern research on the outcome in cancer (cf. RECIST[48]). This is especially the case in patients with gastric cancer as over one-third of those patients have non-measurable disease (e.g., ascites, lymphangitis carcinomatosa, miliary liver metastasis). The concept of ‘clinical benefit response’ (CBR) as a potential addition to QOL deserves mention in this regard[49,50]. CBR combines objective with subjective measures to assess changes in the clinical status of patients.

The recent publication of the EORTC-QLQ-STO22 questionnaire signals a major improvement in the field of assessing QOL in patients with gastric cancer[39]. The questionnaire has five scales (dysphagia, pain, diet, symptoms, emotional problems), and four single items (dry mouth, body image, and hair loss (two items)). The rigorous psychometric testing procedures of the EORTC QOL group suggest that the STO22 will no doubt become one of the standards for assessing QOL in this category of patients. Given the robust nature of this questionnaire, future research will allow examining correlates and predictors of QOL-in various domains, e.g., physiological, psychological, and social. Routinely incorporating the STO22 in clinical research on gastric cancer will improve our knowledge on the impact of gastric cancer and its treatment as perceived by the patient[51,52].

In addition to the EORTC-QLQ-STO22, which is a European-based questionnaire, the FACT-Ga, which was developed in USA, also assesses QOL in patients with gastric cancer. The FACT-Ga as a cancer generic QOL questionnaire has 27 items covering four subscales that assess physical, social/family, emotional, and functional well-beings[8]. The gastric cancer-specific FACT-Ga is under construction and will be available shortly. Dumping syndrome (e.g., postprandial dizziness, cold perspiration) can also be considered when assessing QOL, as addition to gastric cancer-specific QOL questionnaires[50].

The ultimate study will examine the research question: How can we improve QOL in patients with gastric cancer? Medical care has the power to improve QOL. Other treatment strategies may also help improve QOL: self-management training, skills training, and support groups have shown to produce improvements in QOL[53]. In gastric cancer patients, the study by Persson and Glimelius illustrated the positive effects on QOL of a group rehabilitation program combined with individual support[54]. The study by Kuchler et al[55], is a hallmark paper in this regard. In this study, patients with gastrointestinal cancer were randomly allocated to standard care vs additional psychotherapeutic support. Patients in the experimental group survived longer than in the ‘care as usual’ group. Generally, recent meta-analyses demonstrated the positive effects of psychosocial care for cancer patients, as gauged by improvements in QOL[56,57]. Patients, physicians and researchers, therefore, may benefit from developing psychosocial support programs and from examining their effects on behavioral and medical outcomes.

A number of authors emphasize the importance of paying attention to QOL, given the important but as yet relatively modest effects of surgery, chemotherapy or radiotherapy in gastric cancer in particular. Bozzetti writes, “we think that when two surgical procedures are compared, if the oncological results are the same, the operation which is associated with least discomfort and impairment of QOL, should be chosen”[61]. Our review indicates how in empirical studies on gastric cancer QOL has been addressed, assessed and evaluated. Choosing a questionnaire to assess QOL depends entirely on the study topic. There is no ‘best’ QOL questionnaire for patients with gastric cancer. The research question and clinical objectives determine the choice of the QOL instruments. The recent publication of the EORTC-QLQ-STO22 is a breakthrough. However, additional questionnaires are needed to answer specific research questions or to explore other psychosocial issues in patients with gastric cancer, e.g., demand for information by patients or on the partner’s concern and worries[58-60]. Improving the medical care for patients with gastric cancer will ultimately be judged by improvement in survival and QOL. The quotation from ‘Cancer Ward’ at the beginning of our paper intended to help focus our attention on the goal of health care: to help people live longer and feel better[61-64].

ACKNOWLEDGMENTS

We acknowledge the help of Jos Leenes, librarian, for his help with the literature searches, and Wendy van der Putten, for secretarial skills.

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