Basic Research
Copyright ©The Author(s) 2004.
World J Gastroenterol. Jun 1, 2004; 10(11): 1600-1607
Published online Jun 1, 2004. doi: 10.3748/wjg.v10.i11.1600
Table 3 A portion of up-regulated genes in activated HSC
GenBank accession numberGene nameRatio (Cy5/Cy3)Potential gene function
AF061017UDP-glucose dehydrogenase, mRNA complete cds15.56Glycosaminoglycan , hyaluronan and heparin sulfate biosynthesis
X65553mRNA for poly (A) binding protein7.405A regulator of translation initiation
AF029844Elongation factor 1-beta homology mRNA, complete cds6.305Translation factor and has multi-functions
NM_010798Macrophage migration inhibitory factor (Mif), mRNA5.847Proinflammatory peptide and a mediator of growth factor dependent ERK MAP kinase activation and cell cycle progression
M31131Neural cadherin (N-cadherin) mRNA5.559Cell adhesion molecule
AB029930mRNA for caveolin-1 beta isoform4.945Inhibit the eNOS activity
D12618mRNA for nucleosome assembly protein-1, complete cds4.528Histone H2A-H2B shutting protein that promotes histone deposition, and is important for maintaining chromatin structure
M22432Protein synthesis elongation factor Tu (eEF-Yu, eEf-1-1alpha) mRNA, complete cds4.344Translation factor involved in the protein biosynthesis
D31717mRNA for ribophorin4.319Glycoprotein synthesis
NM_012052Ribosomal protein S3 (Rps3), mRNA4.297Protein biosynthesis
X72711mRNA for replication factor C (140 Kda), long subunit4.245DNA synthesis and repair, and a regulator of NF-kappa B
X13460Annexin VI, p68 (Mouse mRNA for p68 protein of the lipocortin family)4.218Calcium binding protein
NM_011290Ribosomal protein L6 (Rp16), mRNA4.089Protein biosynthesis
U12273Apurinic/apyrimidinic endonuclease (APEX) gene, complete cds3.488A DNA repair enzyme and an activator of several transcription factors
D42048mRNA for squalene epoxidase3.298Rate-limiting enzyme of cholesterol biosynthesis
AJ250491mRNA for receptor activity modifying protein 3 (Ramp3) gene3.255Complex with the calcitonin receptor-like receptor, establishing a functional receptor for adrenomedullin
L04280Ribosomal protein (RPL12) mRNA3.172Protein biosynthesis
K02927Ribonucleotide reductase subunit M1 mRNA, complete cds3.156Rate-limiting enzyme in DNA synthesis and repair
AF087568Palmitoyl-protein thioesterase precursor mRNA, complete cds3.059Cell survival signaling
AF020039NADP-dependent isocitrate dehydrogenase (Idh) mRNA, complete cds3.038A key enzyme of the tricarboxylic acid cycle
X57960Ribosomal protein L72.962Protein biosynthesis
U09816GM2 activator protein (Gm2a) mRNA2.888Enzymatic hydrolysis of GM2
AB018575Cdc 7 mRNA, complete cds2.816Essential for G1/S transition
AF041054E1B19K/Bcl-2 binding protein homology (Nip3) mRNA, nuclear gene encoding mitochondria protein, complete cds2.813Nips is a pro-apoptotic mitochondria protein
L04128Ribosomal protein L18 (rpL18) mRNA2.751Protein biosynthesis
Z31554(129/SV) Cctd mRNA for CCT (chaperonin containing TCP-1) delta subunit2.743Stabilize the cytoskeletal protein actin and tubulin
D63784mRNA for MIDA1, complete cds2.703Regulate cell growth
AF026481eIF-1A (eIF-1A) mRNA, complete cds2.682Translation initiation factor
U35249CDK-activating kinase assembly factor p36/MAT1, complete cds2.645An assembly factor and a targeting subunit of cyclin-dependent kinase-activating kinase that is involved in cell cycle control, transcription and DNA repair
M76131Elongation factor (ef-2) mRNA, 3’end2.614Protein biosynthesis
X64713mRNA for cyclin B12.576Cell cycle regulatory protein
D26091mRNA for mCDC47, complete cds2.570A member of the minichromosome maintenance (Mcm) family involve in the DNA replication licensing system
U78085Ribosomal protein S5 mRNA2.507Protein synthesis
AF141322Caveolin-2 mRNA, complete cds2.458Inhibit the eNOS activity
M33934IMP dehydrogenase mRNA, complete cds2.429An enzyme involved in de novo synthesis of guanine nucleotides
U83628Defender against cell death protein 1 (DAD1) mRNA, complete cds2.372Apoptotic suppressor gene