Basic Research
Copyright ©The Author(s) 2004.
World J Gastroenterol. Jun 1, 2004; 10(11): 1600-1607
Published online Jun 1, 2004. doi: 10.3748/wjg.v10.i11.1600
Table 2 Part of the previously reported up-regulated genes in activation of HSC
GenBank accession numberGene nameRatio (Cy5/Cy3)Potential gene function
M73741Alpha-B2-crystallin, complete cds155.619Small heat shock protein gene, an early marker for HSC activation
X52046Procollagen, type III, alpha 1119.092Extracellular matrix (ECM), over- expressed in hepatic fibrosis
M18194Fibronectin mRNA29.958ECM, over expressed in hepatic fibrosis
J02870Laminin receptor mRNA6.62ECM receptor (integrin), cell adhesion
L08115CD9 antigen6.094Cell membrane glycoprotein, involved in cell activation and adhesion
U16163Prolyl 4-hydroxylase alpha (II) - subunit mRNA, complete cds4.555An enzyme which is essential for the collagen synthesis in HSC
X62622TIMP-2 mRNA for tissue inhibitor of metalloproteinase, type 23.732Inhibition for ECM degradation
X04017mRNA for cysteine-rich glycoprotein SPARC3.435Regulation of cell shape, adhesion, migration and proliferation
AF070470SPARC-related protein (SRG) mRNA, complete cds3.181Regulation of cell shape, adhesion, migration
M21495Cytoskeletal gamma-actin mRNA,3.092Relate skeleton structure of cell
AF188297TGF-beta receptor binding protein (Trip1) mRNA, complete cds2.976TGF-beta mediated signaling pathway
AJ245923alpha-tubulin 8 (Tuba 8 gene) mRNA2.901Relate skeleton structure of cell
AF053454Tetraspan TM4SF (Tspan-6) mRNA complete cds,2.896Cell development, differentiation, motility
AF013262Lumican gene, complete cds2.862Small, leucine-rich proteoglycan which involves in the regulation of collagen figril assembly
L02526Protein kinase (MEK) mRNA2.714Signaling molecule in MAPK family
Y00769mRNA for integrin beta subunit2.521Signaling molecular in cell adhesion, proliferation and migration