Expression and activities of three inducible enzymes in the healing of gastric ulcers in rats

Figure 1 Sequential change of ulcer areas at different time points after ulcer induction. Significant decrease of ulcer area was found on day 3 after ulcer induction. The data were represented as mean ± S. E. M of 20 rats in each group, ^aP < 0.05 vs the 2 h group; ^bP < 0.001 vs the 2 h group; ^dP < 0.001 vs the day 1 group.

Figure 2 Time course of mRNA expression of inducible and constitutive isoforms of NOS, HO and COX in the ulcer bases. NC = normal control group.

Figure 3 Western blot analysis of the protein levels of inducible and constitutive isoforms of NOS, HO and COX in the ulcer bases at different time after ulcer induction. NC = normal control group.

Figure 4 Total NOS (tnos) and iNOS (inos) activities at the non-ulcerated tissues (A), margins (B), and ulcer base (C) of acetic acid induced gastric ulcer. Each bar represents the mean ± S.E.M of 8 rats in each group. NC = normal control group.

Figure 5 HO activities in the gastric tissues of normal control rats (NC) and the non-ulcerated tissues, ulcer margins and ulcer bases of acetic acid induced gastric ulcer. Each bar repre-sents the mean ± S. E. M of 8 rats in each group.

Figure 6 COX activities in the gastric tissues of normal control rats (NC) and the non-ulcerated tissues, ulcer margins and ulcer bases of acetic acid induced gastric ulcer. Each bar rep-resents the mean ± S.E.M of 8 rats in each group.