Acute hepatitis C in a chronically HIV-infected patient: Evolution of different viral genomic regions

Figure 1 (A) Biochemical profile of the HIV/HCV superinfected patient during the first 17 mo of follow-up. Amino acid sequences of consecutive samples corresponding to V3 loop (B) and HVR1 (C). V3 loop sequence was obtained in the initial sample (0) and after 2, 17 and 42 mo of follow-up. HVR1 sequences in samples were obtained from 0 to the 17^th month of follow-up and in the 42^th month of follow-up. The number at the left of each sequence corresponded to the month of the follow-up when the samples were sequenced. Nucleotide sequences at the different time points were aligned with CLUSTAL W 1.5, and the corresponding amino acid ones were deduced.

Figure 2 Amino acid sequences of consecutive samples corresponding to HCV NS5A (A) and core (B). The number at the left of each one corresponded to the month of the follow-up when the sequences were done. The black bar indicated the ISDR. Amino acid positions were according to the HCV-1 (M62321).