Liver cell adenoma with malignant transformation: A case report

Figure 1 A: Computed tomography revealing a large tumor in the left lobe. B: Celiac angiography during the arterial phase, showing a large hypervascular lesion.

Figure 2 A: Macroscopic appearance of resected tumor. The tumor was incompletely encapsulated by thin fibrous tissues, and its cut surface was tan-yellowish. Hemorrhage was observed inside part of the tumor. B: Microscopic appearance of tumor. Tumor cells were relatively uniform and had clear eosinophilic cytoplasm with small round nuclei. C: Trabecular structures were spo-radically encountered in association with hemorrhage. D: The tumor cells were arranged predominantly in a thin trabecular pattern with moderate nuclear atypia.

Figure 3 Immunohistochemistry. A: PIVKA-II. B: CD34. PIVKA-II was positive in the tumor cells with or without nuclear atypism and trabecular structure (A). CD34 was expressed diffusely in the sinusoidal endothelial cells (B).