Growth inhibition and apoptosis induction of Sulindac on Human gastric cancer cells

Figure 1 A: Dose-response of sulindac on growth of cell lines by MTT assay (N = 3); B: Dose-response of sulindac on growth of HCC cell lines by MTT assay (N = 3).

Figure 2 Morphological changes of MKN45 and HepG₂. Cells stained with Hoechst 33258 × 400. A: MKN45 cells; B: MKN45 cells treated with 2 mmol•L¯¹ sulindac for 24 h; C: HepG₂ cells; D: HepG₂ cells treated with 400 μmol•L¯¹ sulindac for 24 h.

Figure 3 A: The apoptosis of gastric cancer cells induced by sul indac by Hoechst 33258 staining. (N = 3); B: The apoptosis of 2 HCC cells induced by sulindac by Hoechst 33258 staining. (N = 3)

Figure 4 A: COX-2 protein levels in human gastric cancer and HCC cells with sulindac for 24 h; B: Bcl-2 protein levels in human gastric cancer cells and HCC cells with sulindac for 24 h.