Natural history of asymptomatic subepithelial lesions of the upper gastrointestinal tract: A multicenter study in Korea

Figure 1 Study flowchart. UGI SEL: Upper gastrointestinal subepithelial lesion.

Figure 2 Cumulative risk of lesion size increase. A: Cumulative risk of ≥ 25% size increase; B: Longitudinal lesion changes in cases with a ≥ 25% size increase; C-F: Cumulative risks of ≥ 5 mm (C), ≥ 10 mm (D), from < 1 cm to ≥ 2 cm (E), and from < 2 cm to ≥ 3 cm (F) size increases. The 5-year cumulative risk of a size increase of ≥ 25%, ≥ 5 mm, and ≥ 10 mm are 4.0%, 2.0%, and 0.6%, respectively. Significantly faster growth is observed in lesions ≥ 3 cm at baseline. The cumulative risk for a size increase from < 1 cm to ≥ 2 cm and from < 2 cm to ≥ 3 cm, are 0.4% and 0.1%, respectively.

Figure 3 Cumulative risk for intervention. A and B: Cumulative risks of intervention in the study population (A) and stratified by initial lesion size (B). The 5-year cumulative risk of intervention is 1.0%, with a significantly higher risk observed in lesions with an initial size of ≥ 2 cm. Group-wise comparisons of cumulative risk are also shown: < 1 cm vs 1-2 cm (P = 0.002), < 1 cm vs 2-3 cm (P < 0.001), < 1 cm vs ≥ 3 cm (P < 0.001), 1-2 cm vs 2-3 cm (P < 0.001), 1-2 cm vs ≥ 3 cm (P = 0.001), and 2-3 cm vs ≥ 3 cm (P = 0.420).