Observational Study
Copyright ©The Author(s) 2021.
World J Gastroenterol. Jul 21, 2021; 27(27): 4453-4467
Published online Jul 21, 2021. doi: 10.3748/wjg.v27.i27.4453
Figure 1
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Figure 1 Plasma levels of angiopoietin-1, angiopoietin-2, vascular endothelial growth factor, and alpha fetoprotein in the hepatocellular carcinoma patients according to tumor stage. A: Angiopoietin-1; B: Angiopoietin-2; C: Vascular endothelial growth factor; D: Alpha-fetoprotein. AFP: Alpha-fetoprotein; Ang-1: Angiopoietin-1; Ang-2: Angiopoietin-2; BCLC: Barcelona clinic liver cancer; VEGF: Vascular endothelial growth factor.
Figure 2
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Figure 2 Factors correlated with plasma level of angiopoietin-1, angiopoietin-2 and vascular endothelial growth factor in hepatocellular carcinomas patients with their interrelationship. The heat map showing a red background indicates a positive correlation, the blue background indicates negative correlation, and the numbers in the box indicate rho (ρ). AFP: Alpha-fetoprotein; Ang-1: Angiopoietin-1; Ang-2: Angiopoietin-2; BCLC: Barcelona clinic liver cancer; BMI: Body mass index; MELD: Model for end stage liver disease; NLR: Neutrophil-lymphocyte ratio; PLR: Platelet-lymphocyte ratio; VEGF: Vascular endothelial growth factor.
Figure 3
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Figure 3 Overall survival according to plasma angiogenesis marker level. A: Angiopoietin-1; B: Angiopoietin-2; C: Vascular endothelial growth factor; D: Alpha-fetoprotein. AFP: Alpha-fetoprotein; Ang-1: Angiopoietin-1; Ang-2: Angiopoietin-2; VEGF: Vascular endothelial growth factor; HR: Hazard ratio; CI: Confidence interval.
Figure 4
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Figure 4 Time-dependent receiver operating characteristic for survival at each time point. AFP: Alpha-fetoprotein; Ang-1: Angiopoietin-1; Ang-2: Angiopoietin-2; VEGF: Vascular endothelial growth factor; ROC: Receiver operating characteristic; AUC: Area under the ROC curve.
Figure 5
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Figure 5 Progression-free survival according to plasma angiogenesis marker level. A: Angiopoietin-1; B: Angiopoietin-2; C: Vascular endothelial growth factor; D: Alpha-fetoprotein. AFP: Alpha-fetoprotein; Ang-1: Angiopoietin-1; Ang-2: Angiopoietin-2; VEGF: Vascular endothelial growth factor; HR: Hazard ratio; CI: Confidence interval.