Impact of surgery for chronic pancreatitis on the risk of pancreatic cancer: Untying the Gordian knot

doi:10.3748/wjg.v27.i27.4371

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 21, 2021; 27(27): 4371-4382
Published online Jul 21, 2021. doi: 10.3748/wjg.v27.i27.4371

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Figure 1 Pathogenesis of chronic pancreatitis and chronic pancreatitis-related pancreatic cancer. CASC: Calcium-sensing receptor gene; CFTR: Cystic fibrosis transmembrane conductance regulator gene; CP: Chronic pancreatitis; CTR: Chymotrypsin C gene; PRSS1: Protease serine 1 gene; SPINK 1: Serine peptidase inhibitor Kazal type 1 gene.

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Figure 2 Mechanisms linking chronic pancreatitis and pancreatic cancer. COX-2: Cyclooxygenase-2; FGF: Fibroblast growth factor; IL: Interleukin. TGF-β1: Transforming growth factor β1; TNF: Tumor necrosis factor.

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Figure 3 Proposed risk stratification of chronic pancreatitis patients. CFTR: Cystic fibrosis transmembrane conductance regulator; CLDN2: Tight-junction protein claudin-2; CTRC: Chymotrypsin C; PRSS 1: Protease serine 1; SPINK 1: Serine peptidase inhibitor Kazal type 1.

Citation: Kalayarasan R, Narayanan S, Sahoo J, Mohan P. Impact of surgery for chronic pancreatitis on the risk of pancreatic cancer: Untying the Gordian knot. World J Gastroenterol 2021; 27(27): 4371-4382
URL: https://www.wjgnet.com/1007-9327/full/v27/i27/4371.htm
DOI: https://dx.doi.org/10.3748/wjg.v27.i27.4371