COVID-19-associated diarrhea

doi:10.3748/wjg.v27.i23.3208

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Jun 21, 2021 (publication date) through Apr 19, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 21, 2021; 27(23): 3208-3222
Published online Jun 21, 2021. doi: 10.3748/wjg.v27.i23.3208

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Figure 1 Mechanism involved in coronavirus disease 2019-associated diarrhea. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to its corresponding cell-surface receptor, angiotensin-converting enzyme type 2. In the intestines, SARS-CoV-2 viroporins, E protein, dysregulation of the renin-angiotensin-aldosterone system triggering ionic imbalance, disruption of barrier integrity and inflammation play important roles in the development of coronavirus disease 2019-associated secretory diarrhea and leaky gut. ACE: Angiotensin-converting enzyme; IFN: Interferon; IL: Interleukin; TNFα: tumor necrosis factor alpha; CFTR: CF transmembrane conductance regulator; CaCC: Ca²⁺-activated Cl^- channel; NHE3: Na⁺-H⁺ exchanger 3.

Citation: Megyeri K, Dernovics Á, Al-Luhaibi ZII, Rosztóczy A. COVID-19-associated diarrhea. World J Gastroenterol 2021; 27(23): 3208-3222
URL: https://www.wjgnet.com/1007-9327/full/v27/i23/3208.htm
DOI: https://dx.doi.org/10.3748/wjg.v27.i23.3208