Perioperative blood transfusion decreases long-term survival in pediatric living donor liver transplantation

Figure 1 Patient flowchart. A: Minor complication group (grade I-IIIa) and major complication group (grade IIIb-V); B: Low red blood cell (RBC) volume transfusion group (RBC ≤ 27.5 mL/kg) and high RBC volume transfusion group (RBC > 27.5 mL/kg). LT: Liver transplantation; RBC: Red blood cell; MiC: Minor complication; MaC: Major complication; LTr: Low-volume transfusion; HTr: High-volume transfusion.

Figure 2 Receiver operating characteristic curve. A Receiver operation characteristic curve determined the optimal volume of perioperative red blood cells transfusion related to the presence of major postoperative complication. (Area under the curve = 0.648, P < 0.0001. Sensitivity = 68.7% and specificity = 56.9%. Cutoff point = 27.5 mL/kg; 95%CI: 0.578-0.717).

Figure 3 Patient and graft survival curves. A: Patient survival analysis comparing the minor complication (MiC) group (grade I-IIIa, n = 109) and the major complication (MaC) group (grade IIIb-V, n = 131) with number of patients at risk. Log-rank test: Chi-square = 12.6, degrees of freedom (df) = 1, P = 0.12; B: Graft survival analysis comparing the MiC and MaC groups. Log-rank test: Chi-square = 14.6, df = 1, P = 0.03; C: Patient survival analysis comparing the low-volume transfusion (LTr) group (n = 103) and the high-volume transfusion (HTr) group (n = 137). Log-rank test: Chi-square = 12.6, df = 1, P < 0.001; D: Graft survival analysis comparing the LTr (n = 103) and HTr (n = 137) groups. Log-rank test: Chi-square = 14.6, df = 1, P < 0.001. MiC: Minor complications group (I-IIIa); MaC: Major complications group (IIIb-V); LTr: Low-volume transfusion group; HTr: High-volume transfusion group.