Clinical and prognostic significance of CC chemokine receptor type 8 protein expression in gastrointestinal stromal tumors

Figure 1 Immunohistochemical staining for CC chemokine receptor type 8 in gastrointestinal stromal tumors. A1: High cytoplasmic staining of CC chemokine receptor type 8 (CCR8) in the tissue microarray samples; A2: Specific high positive staining for CCR8 in the cytoplasm; B1: Low cytoplasm staining of CCR8 in gastrointestinal stromal tumor tissues; B2: Specific low positive staining for CCR8 in the cytoplasm; C1 and C2: Negative staining for CCR8. Original magnification: A1, B1, C1 × 40; A2, B2, C2 × 400.

Figure 2 Kaplan–Meier analysis of the relationships between clinicopathological features and overall survival in gastrointestinal stromal tumor patients. A: Overall survival was significantly longer in patients with low CC chemokine receptor type 8 expression than in patients with high CC chemokine receptor type 8 expression; B: Patients with tumor diameter < 5 cm had a better prognosis than patients with diameter 5-10 or > 10 cm; C: Overall survival was significantly longer in patients with mitotic index 0-5 than in patients with mitotic index 6-10 or > 10.