Copyright ©The Author(s) 2020.
World J Gastroenterol. Jun 7, 2020; 26(21): 2702-2714
Published online Jun 7, 2020. doi: 10.3748/wjg.v26.i21.2702
Figure 1
Figure 1 A model of the differential transcription of REG genes in colon crypt cells in Crohn’s disease and ulcerative colitis. Increased interleukin-22 induced transcriptions of REG1/3 in Crohn’s disease (orange solid arrows) are relatively attenuated in ulcerative colitis (orange dotted arrows), leading to CDX2-activated REG transcriptions in ulcerative colitis (black solid arrows), but not in Crohn’s disease (black dotted arrows). IL: Interleukin; TGF: Transforming growth factor; TLR: Toll-like receptor.
Figure 2
Figure 2 A mechanistic model of REG proteins’ protective activities in inflammatory bowel disease. IBD: Inflammatory bowel disease.