Prognostic significance of the fibrinogen-to-albumin ratio in gallbladder cancer patients

Figure 1 Receiver operating characteristics curve analysis based on fibrinogen (A), albumin (B), and fibrinogen to albumin ratio (C) for overall survival. A: The area under the ROC curve (AUC) indicates the diagnostic power of preoperative plasma fibrinogen concentration. In this model, the optimum cut-off point for fibrinogen concentration was 3.47 g/L, AUC was 0.735 (95%CI: 0.654-0.816), with a sensitivity of 0.709 and a specificity of 0.721 by the Youden index; B: The AUC indicates the diagnostic power of preoperative plasma albumin level. In this model, the optimum cut-off point for albumin level was 40.5 g/L, AUC was 0.648 (95%CI: 0.562-0.735), with a sensitivity of 0.647 and a specificity of 0.605 by the Youden index; C: The AUC indicates the diagnostic power of preoperative FAR. In this model, the optimum cut-off point for FAR was 0.08, AUC was 0.783 (95%CI: 0.707-0.859), with a sensitivity of 0.779 and a specificity of 0.765 by the Youden index. ROC: Receiver operating characteristics curve.

Figure 2 Survival curve according to the presence of preoperative fibrinogen concentration (A), albumin level (B), and fibrinogen to albumin ratio (C). A: Data compares fibrinogen concentration > 3.47 g/L vs ≤ 3.47 g/L group (P < 0.05). The number 1 for ≤ 3.47 g/L group, number 2 for > 3.47g/L group; B: Data compares albumin level > 40.5 g/L vs ≤ 40.5 g/L group (P < 0.05). The number 0 for albumin level > 40.5 g/L group, number 1 for albumin level ≤ 40.5 g/L group; C: Data compares FAR > 0.08 vs ≤ 0.08 group (P < 0.05). The number 1 for FAR > 0.08 group, number 0 for FAR ≤ 0.08 g/L group. FAR: Fibrinogen to albumin ratio.