Prognostic significance of combined preoperative fibrinogen and CA199 in gallbladder cancer patients

Figure 1 Receiver operating characteristic curve analysis based on fibrinogen for overall survival. A: The area under the ROC curve (AUC) indicates the diagnostic power of preoperative plasma fibrinogen concentration. In this model, the optimum cut-off point for fibrinogen concentration was 3.47 g/L, AUC was 0.735 (95%CI: 0.654-0.816), with a sensitivity of 0.709 and a specificity of 0.721 by the Youden index. B: AUC indicates the diagnostic power of preoperative CA199 level. In this model, the optimum cut-off point for CA199 level was 25.45 U/mL, AUC was 0.729 (95%CI: 0.650-0.808), with a sensitivity of 0.791 and a specificity of 0.574 by the Youden index. AUC: Area under curve. ROC: Receiver operating characteristic curve.

Figure 2 Survival curve according to the preoperative fibrinogen concentration (A) and CA199 level (B). A: Data compares fibrinogen concentration > 3.47 g/L vs ≤ 3.47 g/L group (P < 0.05). The number 1 for ≤ 3.47 g/L group, number 2 for > 3.47 g/L group. B: Data compares CA199 level > 25.45 U/mL vs ≤ 25.45 U/mL (P < 0.05). The number 1 for ≤ 25.45 U/mL group, number 2 for > 25.45 U/mL group.

Figure 3 Survival curve according to the combined fibrinogen and CA199 scoring system. Data compares the fibrinogen concentration > 3.47 g/L with CA199 level > 25.45 U/mA group, fibrinogen concentration > 3.47 g/L with CA199 level ≤ 25.45 U/mL group, fibrinogen concentration ≤ 3.47 g/L with CA199 level > 25.45 U/mL group and fibrinogen concentration ≤ 3.47 g/L with CA199 level ≤ 25.45 U/mL group. The number 0 for fibrinogen concentration > 3.47 g/L with CA199 level > 25.45 U/mL group, number 1 for fibrinogen concentration > 3.47g/L with CA199 level ≤ 25.45 U/mL group, number 1.1 for fibrinogen concentration ≤ 3.47 g/L with CA199 level > 25.45 U/mL group, number 2.1 for fibrinogen concentration ≤ 3.47 g/L with CA199 level ≤ 25.45 U/mL group.

Figure 4 Receiver operating characteristic curve analysis based on the combination of fibrinogen and CA199 for overall survival. AUC indicates the diagnostic power of the combination of fibrinogen and CA199. In this model, AUC was 0.765 (95%CI: 0.688-0.841). AUC: Area under curve.