P-glycoprotein multidrug transporter in inflammatory bowel diseases: More questions than answers

Figure 1 Xenobiotics, microbiota and host innate immunity interact in a multi-dimensional network in the gut. Disturbances of this equilibrium may alter xenobiotic metabolism via ABCB1/MDR1 p-gp, favoring either drug toxicity or resistance in inflammatory bowel disease. However, these multiple interrelations remain to be further elucidated. P-gp: P-glycoprotein.