Efficacy of combination therapy with natriuretic and aquaretic drugs in cirrhotic ascites patients: A randomized study

Figure 1 Study flow diagram.

Figure 2 Change in mean body weight from baseline on the final dosing day. Comparisons between the combination and conventional diuretic groups were performed using Student’s t test.

Figure 3 Time-course change in body weight from the baseline after administration of the trial drugs. Data are expressed as mean ± SD. Comparisons between final and baseline values for each group were performed using the paired t test. Paired t test: ^bP < 0.01, ^dP < 0.001, ^fP < 0.0001; Student's t test ^aP < 0.05.

Figure 4 Time-course change in urinary volume from the baseline after administration of the trial drugs. Data are expressed as mean ± SD. Comparisons between final values and baseline values for each group were performed using the paired t test, ^bP < 0.01, ^dP < 0.001, ^fP < 0.0001. Comparisons between the groups were performed using Student’s t test, ^gP < 0.05, ^hP < 0.001.

Figure 5 Change in the ascites volume from baseline on the final dosing day. Comparisons between the combination diuretic and conventional diuretic groups were performed using Student’s t test.

Figure 6 Changes in aldosterone, arginine vasopressin and renin from the baseline after administration of drugs. Comparisons between final values and baseline values for each group were performed using the Wilcoxon signed-rank test, ^bP < 0.01; ^dP < 0.001. Comparisons between the groups were performed using the Mann-Whitney U test, ^aP < 0.05.

Figure 7 Changes in 24-creatinine clearance and body weight from the baseline after administration of drugs. Comparisons between final values and baseline values for each group were performed using the Wilcoxon signed-rank test, ^bP < 0.01. Comparisons between the groups were performed using the Mann-Whitney U test.

Figure 8 Changes in ammonia and body weight from baseline after administration of drugs. Comparisons between final values and baseline values for each group were performed using the Wilcoxon signed-rank test, ^bP < 0.01. Comparisons between the groups were performed using the Mann-Whitney U test, ^aP < 0.05.