Biliary tract cancer stem cells - translational options and challenges

doi:10.3748/wjg.v23.i14.2470

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Apr 14, 2017 (publication date) through Apr 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 14, 2017; 23(14): 2470-2482
Published online Apr 14, 2017. doi: 10.3748/wjg.v23.i14.2470

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Figure 1 Cancer stem cells in biliary tract cancer. Biliary tract cancer stem cells are thought to originate from various subpopulations of healthy cells that harbor stem cell or stem cell-like traits. Currently available data on clinical biliary tract cancer (BTC) specimens revealed up-regulation of established cancer stem cells (CSC) cell surface and functional markers as well as aberrant activity of signaling pathways and micro-RNA species. Expression of CSC markers and stemness factors in BTC tissues is associated with diverse unfavorable clinico-pathological features and poor prognosis. See text for details.

Citation: Mayr C, Ocker M, Ritter M, Pichler M, Neureiter D, Kiesslich T. Biliary tract cancer stem cells - translational options and challenges. World J Gastroenterol 2017; 23(14): 2470-2482
URL: https://www.wjgnet.com/1007-9327/full/v23/i14/2470.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i14.2470