Impact of interferon-free antivirus therapy on lipid profiles in patients with chronic hepatitis C genotype 1b

Figure 1 Longitudinal changes in serum total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglyceride during and after the treatment in DCV + ASV-SVR group. Mean value of serum TC, LDL-C, HDL-C, and TG at baseline (0W), 4 wk (4W), 8 wk (8W), 12 wk (12W), and 24 wk (24W) of DCV + ASV treatment and 4 wk (P4W) and 12 wk (P12W) after the end of DCV + ASV treatment was plotted. Vertical line expressed the range of mean ± SD. Statistical significance from baseline was indicated at upper part of each graph. Statistical significance at P4W and P12W compared to the end of therapy was indicated at the lower part of each graph (^aP < 0.05, ^bP < 0.01, ^eP < 0.001). DCV: Daclatasvir; ASV: Asunaprevir; TC: Total cholesterol; LDL-C: Low-density lipoprotein cholesterol; HDL-C: High-density lipoprotein cholesterol; TG: Triglyceride.

Figure 2 Longitudinal changes in serum total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglyceride during and after the treatment in SOF + LDV-SVR group. Mean value of serum TC, LDL-C, HDL-C, TG at baseline (0W), 4 wk (4W), 8 wk (8W), 12 wk (12W) of SOF + LDV treatment and 4 wk (P4W), and 12 wk (12W) after the end of SOF + LDV treatment was plotted. Vertical line expressed the range of mean ± SD. Statistical significance from baseline was indicated at upper part of each graph. Statistical significance at P4W and P12W compared to the end of therapy was indicated at the lower part of each graph (^bP < 0.01, ^eP < 0.001). SOF: Sofosbuvir; LDV: Ledipasvir; TC: Total cholesterol; LDL-C: Low-density lipoprotein cholesterol; HDL-C: High-density lipoprotein cholesterol; TG: Triglyceride.

Figure 3 Differences in the ΔTC (A), ΔLDL-C (B) between DCV + ASV-SVR and SOF + LDV-SVR group. The mean value of the difference from the baseline value in TC and LDL-C was plotted. Vertical line expressed the range of mean ± SD. The difference of ΔTC and ΔLDL-C between DCV + ASV-SVR and SOF + LDV-SVR group at 4 wk (4W), 8 wk (8W), and 12 wk (12W) of treatment and 4 wk (P4W) and 12 wk (12W) after the end of treatment. Statistical significance of differences between DCV + ASV-SVR and SOF + LDV-SVR group at 4W, 8W, 12W, P4W, and P12W was expressed at the upper part of each graph (^eP < 0.001). DCV + ASV: Daclatasvir plus Asunaprevir therapy, SOF + LDV: Sofosbuvir plus Ledipasvir therapy, TC: Total cholesterol; LDL-C: Low-density lipoprotein cholesterol; HDL-C: High-density lipoprotein cholesterol; TG: Triglyceride.

Figure 4 Longitudinal changes in serum total cholesterol and low-density lipoprotein cholesterol during and after the treatment in DCV + ASV-nSVR group. Mean value of serum TC and LDL-C at baseline (0W), 4 wk (4W), 8 wk (8W), 12 wk (12W), and 24 wk (24W) of DCV + ASV treatment and 4 wk (P4W) and 12 wk (P12W) after the end of DCV + ASV treatment was plotted. Vertical line expressed the range of mean ± SD. Statistical significance from baseline was indicated at upper part of each graph (^aP < 0.05). DCV: Daclatasvir; ASV: Asunaprevir; TC: Total cholesterol; LDL-C: Low-density lipoprotein cholesterol.