Molecular genetics and targeted therapeutics in biliary tract carcinoma

doi:10.3748/wjg.v22.i4.1335

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Jan 28, 2016 (publication date) through Apr 25, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 28, 2016; 22(4): 1335-1347
Published online Jan 28, 2016. doi: 10.3748/wjg.v22.i4.1335

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Figure 1 Molecular and genetic changes that occur during pathogenesis of malignant neoplasms in the biliary tract. BilIN: Biliary intraepithelial neoplasm; CIS: Carcinoma in situ; COX2: Cyclooxygenase 2; FHT: Fragile histidine triad; GB: Gall bladder; HER2: Human epidermal growth factor receptor 2; iNOS: Inducible nitric oxide synthase; IPNB: Intraepithelial papillary neoplasm of the bile duct; LOH: Loss of heterozygosity; MUC5AC: Mucin core protein 5AC.

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Figure 2 Targeted agents and their sites of action in biliary tract carcinoma.

Citation: Marks EI, Yee NS. Molecular genetics and targeted therapeutics in biliary tract carcinoma. World J Gastroenterol 2016; 22(4): 1335-1347
URL: https://www.wjgnet.com/1007-9327/full/v22/i4/1335.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i4.1335