Cyclophosphamide-associated enteritis: A rare association with severe enteritis

Figure 1 Initial computed tomography of abdomen showing diffuse mural thickening of the small and large bowel. Approximately 2 wk following cyclophosphamide treatment.

Figure 2 Denuded small and large bowel mucosa on endoscopic evaluation. Approximately 4 wk following cessation of cyclophosphamide. A: Duodenum; B: Descending colon.

Figure 3 Post-mortem histopathology. A: Small bowel. The high power view of small bowel shows focal full thickness mucosal ulceration with inflamed granulation tissue and preservation of the muscularis mucosae (arrow); B: Colon. Endoscopic biopsy of the left colon approximately one month after commencing cyclophosphamide showed surface fibrin exudate (short arrow), severe mucosal ulceration and granulation tissue with a few residual glands (arrowheads). There were no viral inclusions or granulomas. Preserved muscularis mucosae is seen (long arrows). Hematoxylin-eosin staining, magnification × 100.