Predicting malignant transformation of esophageal squamous cell lesions by combined biomarkers in an endoscopic screening program

Figure 1 Curves for predicting esophageal lesions based on positive expression of the three biomarkers. These ROC curves are for ESCC (A), HGD (B), LGD (C), and BCH (D), respectively. Note: If the expression of any one of the three biomarkers was positive, the combined expression was counted as positive; if there was an overlap in expression, the score of the strongest expression was taken as the score of the combination. ESCC: Esophageal squamous cell cancer; HGD: High-grade dysplasia; LGD: Low-grade dysplasia; BCH: Basal cell hyperplasia; ROC: Receiver operating characteristic curve.